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Article
Open AccessPharmacokinetic Comparison of a Fixed-Dose Combination of Candesartan Cilexetil/Amlodipine/Atorvastatin Versus Co-administration of Individual Formulations in Healthy Participants
Fixed-dose combinations (FDCs) of angiotensin II receptor blockers, calcium channel blockers, and statins are conventional therapeutic interventions prescribed for cardiovascular diseases. This study aimed at ...
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Article
Open AccessAngiotensin Receptor Blockers and the Risk of Suspected Drug-Induced Liver Injury: A Retrospective Cohort Study Using Electronic Health Record-Based Common Data Model in South Korea
Angiotensin receptor blockers are widely used antihypertensive drugs in South Korea. In 2021, the Korea Ministry of Food and Drug Safety acknowledged the need for national compensation for a drug-induced liver...
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Article
Open AccessProton-pum** photoreceptor controls expression of ABC transporter by regulating transcription factor through light
Light is a significant factor for living organisms with photosystems, like microbial rhodopsin—a retinal protein that functions as an ion pump, channel, and sensory transduction. Gloeobacter violaceus PCC7421, ha...
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Article
Open AccessA SEER-based analysis of trends in HPV-associated oropharyngeal squamous cell carcinoma
The proportional trends of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) according to various factors have not been analyzed in detail in previous studies. We aimed to evaluate the trends of HPV...
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Article
Recipient blood group does not affect hepatocellular carcinoma recurrence after living donor liver transplantation in Korea
This study assessed whether or not the ABO blood type affects the incidence of HCC recurrence after living donor liver transplantation (LDLT).
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Article
Safety and outcome of treatment of latent tuberculosis infection in liver transplant recipients
Liver transplant (LT) recipients have an increased risk of tuberculosis (TB), which is associated with higher mortality rates. This retrospective cohort study assessed the outcome and tolerability of screening...
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Article
Open AccessHeliorhodopsin-mediated light-modulation of ABC transporter
Heliorhodopsins (HeRs) have been hypothesized to have widespread functions. Recently, the functions for few HeRs have been revealed; however, the hypothetical functions remain largely unknown. Herein, we inves...
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Article
Open AccessPrediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion
Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decision...
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Article
Open AccessProminent transcriptomic changes in Mycobacterium intracellulare under acidic and oxidative stress
Mycobacterium avium complex (MAC), including Mycobacterium intracellulare is a member of slow-growing mycobacteria and contributes to a substantial proportion of nontuberculous mycobacterial lung disease in human...
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Article
Inkjet printing MoS2 nanosheets for hydrogen sensing applications
2D nanomaterials are of great interest in many modern applications. In particular, MoS2 nanomaterial with a narrow band gap of 1.8 eV is expected as one of the best candidates for low-cost gas sensors. To reduce ...
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Article
Safety of right liver donation after improving steatosis through weight loss in living donors: a retrospective study
Living donor liver transplantation using hepatic steatosis-improved grafts mitigates donor shortage. Herein, we aimed to evaluate the safety and feasibility of right-lobe adult-to-adult living donor liver tran...
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Article
Open AccessPolygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks
Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design l...
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Article
Open AccessBCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice
The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a protective pathogen-specific immune response while circumventing detrimental inflammation w...
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Open AccessSynergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that...
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Article
Open AccessVortex nanolaser based on a photonic disclination cavity
Optical vector vortex beams provide additional degrees of freedom for spatially distinguishable channels in data transmission. Although several coherent light sources carrying a topological singularity have be...
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Article
Open AccessA Practical Inverse Identification of Johnson–Cook Parameters at Intermediate Strain Rates Using Split Hopkinson Pressure Bar Test
A practical inverse method based on the hybrid experiment-finite element (FE) simulation is proposed for identifying strain rate sensitivity of a metal covering intermediate to dynamic loading conditions. The ...
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Article
Open AccessIdentification and characterization of a marine bacterium extract from Mameliella sp. M20D2D8 with antiviral effects against influenza A and B viruses
Despite significant improvements in vaccines and chemotherapeutic drugs, pathogenic RNA viruses continue to have a profound impact on the global economy and pose a serious threat to animal and human health thr...
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Article
Open AccessLactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model
Atopic dermatitis (AD) is a chronic inflammatory skin disease with repeated exacerbations of eczema and pruritus. Probiotics can prevent or treat AD appropriately via modulation of immune responses and gut mic...
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Article
Open AccessBenefits of statin therapy within a year after kidney transplantation
Cardiovascular disease remains a leading cause of morbidity and mortality after kidney transplantation (KT). Although statins reduce cardiovascular risk and have renal benefits in the general population, their...
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Article
Open AccessTRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression, apoptosis, and differentiation. Dysregulation of this syste...
