4 Result(s)
within
**-Gu Han
Medicine & Public Health
Medicine/Public Health, general
Oncology
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Article
Open AccessMetabolomic profiling of exosomes reveals age-related changes in ovarian follicular fluid
Female fertility declines with increased maternal age, and this decline is even more rapid after the age of 35 years. Follicular fluid (FF) is a crucial microenvironment that plays a significant role in the de...
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Article
Open AccessReduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer; however, specific prognostic biomarkers have not yet been developed. In this study, we identified dysregulated microRNAs (m...
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Article
Open AccessInhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer
Checkpoint kinase 1 (Chk1) expression is enhanced in most cancers owing to oncogenic activation and constant replicative stress. Chk1 inactivation is a promising cancer therapy, as its inactivation leads to ge...
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Article
Rapid blockade of telomerase activity and tumor cell growth by the DPL lipofection of ribbon antisense to hTR
Ribbon antisense (RiAS) to the hTR RNA, a component of the telomerase complex, was employed to inhibit telomerase activity and cancer cell growth. The antisense molecule, hTR-RiAS, combined with enhanced cellu...
