1,027 Result(s)

Article

Exploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)

Bilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic properties. The systemic immune-inflammation index (SII) is a recent marker tha...

Shan-Shan Huang, Yi Ding, **ao-Na Yi, Hai-Yan Mao… in European Journal of Medical Research (2024)

Article

A positive feedback loop between PFKP and c-Myc drives head and neck squamous cell carcinoma progression

The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial role in the development of various human cancers by modifying diverse biological functions. However, the precise molecular mechani...

Weiwei Liu, Zhao Ding, Ye Tao, Shixian Liu, Maoyu Jiang, Fangzheng Yi… in Molecular Cancer (2024)

Article

A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis

Metastasis is the leading cause of mortality in patients with colorectal cancer (CRC) and angiogenesis is a crucial factor in tumor invasion and metastasis. Long noncoding RNAs (lncRNAs) play regulatory functi...

Lisha Chang, Jie Ding, Juan Pu, **g Zhu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Pyroptosis-related long-noncoding RNA signature predicting survival and immunotherapy efficacy in patients with lung squamous cell carcinoma

Pyroptosis-related long-noncoding RNAs (PRlncRNAs) play an important role in cancer progression. However, their role in lung squamous cell carcinoma (LUSC) is unclear. A risk model was constructed using the le...

**ang Zhan, Jixian Li, Yi Ding, Fengge Zhou… in Clinical and Experimental Medicine (2024)

Article

TCBIR/CD320: a potential therapeutic target upregulated in endothelial cells and associated with immune cell infiltration in liver hepatocellular carcinoma

CD320, which is a transmembrane protein responsible for facilitating the absorption of vitamin B12, plays a key role in this process. However, the relationships between CD320 and immune cell infiltration level...

Shubin Zhang, Zhongyi Jiang, Pusen Wang, Weihao Jiang, Wei Ding… in Discover Oncology (2024)

Article

Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis

The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism of the crosstalk between cells in the pathogen...

Yulin Wang, Ziyan Shen, Shaocong Mo, Han Zhang, **g Chen, Cheng Zhu… in Human Cell (2024)

Article

Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment

Cancer, a prevalent and complex disease, presents a significant challenge to the medical community. It is characterized by irregular cell differentiation, excessive proliferation, uncontrolled growth, invasion...

Haihong Lin, Jun Zhou, Tao Ding, Yifan Zhu… in European Journal of Medical Research (2024)

Article

Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer

This study aimed to develop a novel six-gene expression biomarker panel to enhance the early detection and risk stratification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer (L...

**’an Ding, Haotian Wu, Jiaxiang Wu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity

CD8⁺ T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane ectodomain shedding is an important post-translational process or...

Lina Sun, Anjun Jiao, Haiyan Liu, Renyi Ding… in Signal Transduction and Targeted Therapy (2024)

Article

Mechanistic insights into ¹²⁵I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2

Cholangiocarcinoma (CCA) is a rare tumor with a poor prognosis and poses significant therapeutic challenges. Herein, we investigated the mechanism of efficacy of ¹²⁵I seed implantation therapy in CCA, focusing on...

Jun Luo, Zheng Yao, Weiren Liang… in Journal of Cancer Research and Clinical On… (2024)

Article

Acute kidney injury in cancer patients receiving anti-vascular endothelial growth factor monoclonal antibody vs. immune checkpoint inhibitors: a retrospective real-world study

Anti-vascular endothelial growth factor monoclonal antibody (anti-VEGF) or immune checkpoint inhibitors (ICIs) combined with chemotherapy are commonly administered to cancer patients. Although cancer patients ...

Jianfen Zhu, **aokai Ding, Jianna Zhang, Bo Chen, **aohan You, **nxin Chen… in BMC Cancer (2024)

Article

IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide. Inhibitor of kappa B kinase interacting protein (IKBIP) has been reported to promote glioma progression, but its role in o...

Jiannan Hu, Chuan**g Dai, Zhaoji Ding, Yixiao Pan, Lingxiao Lu, Jiaqian Bao… in BMC Cancer (2024)

Article

Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis

Circular RNAs (circRNAs) play important roles in cancer progression and metastasis. However, the expression profiles and biological roles of circRNAs in non-small cell lung cancer (NSCLC) remain unclear.

Maoye Wang, **aoge Ding, **njian Fang, **g Xu, Yanke Chen, Yu Qian… in Molecular Cancer (2024)

Article

Anesthesia management for extended resection of thymic tumor combined with artificial bypass between the innominate vein and the right atrial appendage

YuanYuan Ma, JianYong Ding, Sheng** Ge in Clinical Cancer Bulletin (2024)

Article

Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy

The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...

Cheng-Fei Du, Zhen-Yu Gao, Zhu-Ding Xu, Zheng-Kang Fang, Zi-Chen Yu… in BMC Cancer (2024)

Article

Silencing immune-infiltrating biomarker CCDC80 inhibits malignant characterization and tumor formation in gastric cancer

Tumor immune infiltration leads to poor prognosis of gastric cancer patients and seriously affects the life quality of gastric cancer patients. This study was based on bioinformatics to screen prognostic bioma...

MeiHong Yu, **gxuan Peng, Yanxu Lu, Sha Li, Ke Ding in BMC Cancer (2024)

Article

Biomarker conversion from primary breast cancer to synchronous axillary lymph node metastasis and neoadjuvant therapy response: a single-center analysis

The biomarker characteristics of breast cancer plays an important role in predicting treatment sensitivity. The aim of the present study was to compare immunohistochemical profiles (ER, PR, HER2, and Ki67) bet...

Mao Ding, Mengyuan Li, Qian Liu… in Journal of Cancer Research and Clinical Oncology (2024)

Article

OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway

Intestinal metaplasia (IM) is classified into complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM). Patients diagnosed with IIM face an elevated susceptibility to the development of ...

Hongfa Wei, Wenchao Li, Leli Zeng, Ni Ding, Kuan Li, Hong Yu, Fei Jiang… in Molecular Cancer (2024)

Article

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...

Sihui Luo, Xueying Zheng, Wei Bao, Sheng Nie… in Signal Transduction and Targeted Therapy (2024)

Article

Constructing a prognostic model for colorectal cancer with synchronous liver metastases after preoperative chemotherapy: a study based on SEER and an external validation cohort

The combination of preoperative chemotherapy and surgical treatment has been shown to significantly enhance the prognosis of colorectal cancer with liver metastases (CRLM) patients. Nevertheless, as a result o...

Yixin Ding, **aoxi Han, Shufen Zhao, Shasha Wang… in Clinical and Translational Oncology (2024)