49 Result(s)
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Open AccessExploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)
Bilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic properties. The systemic immune-inflammation index (SII) is a recent marker tha...
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Open AccessTherapeutic potential of extracellular vesicles from diverse sources in cancer treatment
Cancer, a prevalent and complex disease, presents a significant challenge to the medical community. It is characterized by irregular cell differentiation, excessive proliferation, uncontrolled growth, invasion...
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Open AccessHE4-based nomogram for predicting overall survival in patients with idiopathic pulmonary fibrosis: construction and validation
Idiopathic pulmonary fibrosis (IPF) is a life-threatening interstitial lung disease. Identifying biomarkers for early diagnosis is of great clinical importance. The epididymis protein 4 (HE4) is important in t...
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Open AccessAssociations between Life’s Essential 8 and post-stroke depression and all-cause mortality among US adults
Depression is the common mental disease after stroke. Our objective was to investigate the correlation of Life’s Essential 8 (LE8), the recently updated evaluation of cardiovascular health, with the occurrence...
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Open AccessSerum PYCARD may become a new diagnostic marker for rheumatoid arthritis patients
The objective of this investigation is to analyze the levels and clinical relevance of serum PYCARD (Pyrin and CARD domain-containing protein, commonly known as ASC—apoptosis-associated speck-like protein cont...
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Open AccessPhthalate exposure and blood pressure in U.S. children aged 8–17 years (NHANES 2013–2018)
Current evidence from epidemiologic studies suggested that phthalate metabolites might be associated with blood pressure (BP) changes. However, the special relationship between phthalate metabolites and BP cha...
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Open AccessDiagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein (COMP) and ADAMTS7 (A disintegrin and m...
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Open AccessTR4 worsen urosepsis by regulating GSDMD
Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection. The aim of this stud...
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Open AccessAnalysis of relevant factors influencing size of breast abscess cavity during lactation: a cross-sectional study
The aim of this study was to investigate risk factors for the severity of breast abscess during lactation.
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Open AccessMean compression ratio of a self-expandable valve is associated with the need for pacemaker implantation after transcatheter aortic valve replacement
The risk and timing of permanent pacemaker implantation (PPMI) after transcatheter aortic valve replacement (TAVR) is still hard to predict. We aimed to analyze the relationship between the compression ratio o...
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Open AccessIdentification of potential crucial genes and therapeutic targets for epilepsy
Epilepsy, a central neurological disorder, has a complex genetic architecture. There is some evidence suggesting that genetic factors play a role in both the occurrence of epilepsy and its treatment. However, ...
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Open AccessCurrent progression in application of extracellular vesicles in central nervous system diseases
Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood–brain barrier. Specific proteins...
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Open AccessUbiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
Cholangiocarcinoma is the most common malignant bile duct tumor in Southeast Asia. The special location of cholangiocarcinoma leads to it being difficult to diagnose. Currently, the progress in clinical progno...
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Open AccessSNAP25 is a potential target for early stage Alzheimer’s disease and Parkinson’s disease
Alzheimer’s disease (AD) and Parkinson’s disease (PD), two common irreversible neurodegenerative diseases, share similar early stage syndromes, such as olfaction dysfunction. Yet, the potential comorbidity mec...
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Open AccessHigher plasma aldosterone concentrations in patients with aortic diseases and hypertension: a retrospective observational study
Aortic diseases remain a highly perilous macrovascular condition. The relationship between circulating aldosterone and aortic diseases is rarely explored, thus we investigated the difference in plasma aldoster...
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Open AccessMechanisms and biomarkers of immune-related adverse events in gastric cancer
Immune-checkpoint inhibitors (ICIs), different from traditional cancer treatment models, have shown unprecedented anti-tumor effects in the past decade, greatly improving the prognosis of many malignant tumors...
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Open AccessA review on recent advances on nobiletin in central and peripheral nervous system diseases
In recent years, the role of nobiletin in neuronal disorders has received extensive attention. However, the study of nobiletin in the peripheral nervous system is limited. Nobiletin, as a compound with high fa...
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Open AccessLymphangiogenesis in gastric cancer: function and mechanism
Increased lymphangiogenesis and lymph node (LN) metastasis are thought to be important steps in cancer metastasis, and are associated with patient's poor prognosis. There is increasing evidence that the lympha...
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Open AccessClinical significance of interleukin-6, total bilirubin, CD3 + CD4 + T cells counts in the acute exacerbation of connective tissue disease-associated interstitial lung disease: a cross-sectional study
Interstitial lung disease (ILD) is a severe complication of connective tissue disease (CTD) that can significantly impact patients' prognosis and quality of life. However, the current diagnostic arena lacks re...
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Open AccessDevelopment and validation of a competitive risk model in patients with rectal cancer: based on SEER database
Rectal cancer is one of the most common malignancies. To predict the specific mortality risk of rectal cancer patients, we constructed a predictive nomogram based on a competing risk model.
