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427 Result(s)
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Article
Erratum: Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines
Correction to: Leukemia (2005) 19, 420–426. doi: 10.1038/sj.leu.2403639 It has been identified by the authors that the primer sequences for amplification of human ASY cDNA in quantitative real-time RT-PCR as g...
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Erratum: Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response
Correction to: Oncogene (2008) 27, 931–941; doi:10.1038/sj.onc.1210710; published online 20 August 2007 Owing to typesetting errors, three authors were omitted from the author list. The corrected list and affi...
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High expressions of vascular endothelial growth factor and platelet-derived endothelial cell growth factor predict poor prognosis in alpha-fetoprotein-negative hepatocellular carcinoma patients after curative resection
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Open AccessCharacterization of High-Fat, Diet-Induced, Non-alcoholic Steatohepatitis with Fibrosis in Rats
An ideal animal model is necessary for a clear understanding of the etiology, pathogenesis, and mechanisms of human non-alcoholic steatohepatitis (NASH) and for facilitating the design of effective therapy for...
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Erratum to: Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1
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Open AccessExpression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
Hypoxia in tumors is generally associated with chemoresistance and radioresistance. However, the correlation between the heterodimeric hypoxia-inducible factor-1 (HIF-1) and the multidrug resistance (MDR1) gen...
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Open AccessHLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the ea...
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Open AccessThe influence of family history and histological stratification on breast cancer risk in women with benign breast disease: a meta-analysis
Benign breast disease (BBD) is an important risk factor for subsequent breast cancer. However, it is unclear whether breast cancer risk is higher in cases of atypical ductal hyperplasia (ADH) than atypical lob...
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Open AccessGEIRA: gene-environment and gene–gene interaction research application
The GEIRA (Gene-Environment and Gene–Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene–gene interaction analysis. It implements conce...
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Open AccessMicrobiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study
Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells. It has been shown that porc...
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Open AccessmiR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma
Epithelial-to-mesenchymal transition (EMT) is associated with poor prognosis and metastasis in hepatocellular carcinoma. We have previously demonstrated an in vivo model of liver cancer in which mesenchymal cells...
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Open AccessEffects and mechanism of duodenal-jejunal bypass and sleeve gastrectomy on GLUT2 and glucokinase in diabetic Goto–Kakizaki rats
The study investigated the effects and mechanism of duodenal-jejunal bypass (DJB) and sleeve gastrectomy (SG) on the expression of liver GLUT2 and glucokinase (GCK) in diabetic rats.
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Open AccessThe significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
This study was aimed to investigate the significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received 18F-FDG PET/CT scan at initial diagnosis. Al...
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Open AccessHomozygous A polymorphism of the complement C1qA 276 correlates with prolonged overall survival in patients with diffuse large B cell lymphoma treated with R-CHOP
The precise mechanism of action for rituximab (R) is not fully elucidated. Besides antibody-dependent cellular cytotoxicity (ADCC), complements may also play an important role in the clinical response to ritux...
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The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans
In a murine model, we have linked early life toxicant exposure to reduced uterine sensitivity to progesterone, a phenotype we had previously associated with inflammation in endometriosis patients. Subsequent s...
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Open AccessA novel monoclonal antibody of human stem cell factor inhibits umbilical cord blood stem cell ex vivo expansion
Stem cell factor (SCF) activates hematopoietic stem cell (HSC) self-renewal and is being used to stimulate the ex vivo expansion of HSCs. The mechanism by which SCF supports expansion of HSCs remains poorly un...
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Open AccessTracheal stenting for primary tracheal mucosa-associated lymphoid tissue lymphoma
Primary tracheal mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare. We report a 49-year-old female patient with the complaint of dyspnea. Fiberoptic bronchoscopy showed polypoid, variable-siz...
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Open AccessDirect effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation
Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression of the MycN oncoprotein in emb...
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Open AccessClinical significance of the uPA system in gastric cancer with peritoneal metastasis
It has been demonstrated that urokinase-type plasminogen activator (uPA) is involved in tumor cell metastasis by degrading the extracellular matrix. However, there is little direct evidence of clinical uPA sys...
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Open AccessAnalysis of UGT1A1*28 genotype and SN-38 pharmacokinetics for irinotecan-based chemotherapy in patients with advanced colorectal cancer: results from a multicenter, retrospective study in Shanghai
The UGT1A1*28 polymorphism, although closely linked with CPT-11-related adverse effects, cannot be used alone to guide individualized treatment decisions. However, CPT-11 dosage can be adjusted according to m...