448 Result(s)

Article

Correction: MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma

Qin Tang, Wan Li, **ang** Zheng, Liwen Ren… in Signal Transduction and Targeted Therapy (2024)

Article

Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study

Esophageal cancer (EC) is a highly lethal disease lacking early detection approaches. We previously identified that OTOP2 and KCNA3 were specifically hypermethylated in circulating cell-free DNA from patients ...

Yan Bian, Ye Gao, Han Lin, Chang Sun, Wei Wang… in Journal of Hematology & Oncology (2024)

Article

Whole-tumoral metabolic heterogeneity in ¹⁸F-FDG PET/CT is a novel prognostic marker for neuroblastoma

Neuroblastoma (NB) is a highly heterogeneous tumor, and more than half of newly diagnosed NB are associated with extensive metastases. Accurately characterizing the heterogeneity of whole-body tumor lesions re...

Jun Liu, Qinghua Ren, Haonan **ao, Siqi Li, Lingling Zheng, Xu Yang… in Cancer Imaging (2024)

Article

Deciphering the role of zinc homeostasis in the tumor microenvironment and prognosis of prostate cancer

Dysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and experimental evidence. Nevertheless, the implications of zinc dyshomeo...

Tao Guo, Jian Wang, **angyu Meng, Ye Wang, Yihaoyun Lou, Jianglei Ma… in Discover Oncology (2024)

Article

Exploring GZMK as a prognostic marker and predictor of immunotherapy response in breast cancer: unveiling novel insights into treatment outcomes

Granzyme K (GZMK) is a crucial mediator released by immune cells to eliminate tumor cells, playing significant roles in inflammation and tumorigenesis. Despite its importance, the specific role of GZMK in brea...

Zitao Li, Qiqi **e, Fuxing Zhao, **nfa Huo… in Journal of Cancer Research and Clinical On… (2024)

Article

SIRPG expression positively associates with an inflamed tumor microenvironment and response to PD-1 blockade

This study aimed to investigate the relationship between signal regulatory protein gamma (SIRPG) and tumor immune microenvironment phenotypes or T cell mediated-adaptive antitumor immunity, and its predictive ...

Libo Luo, Minlin Jiang, Hong Wu, Yiqiang Liu… in Cancer Immunology, Immunotherapy (2024)

Article

Is neoadjuvant chemotherapy necessary for T2N0-1M0 hormone receptor-positive/HER2-negative breast cancer patients undergoing breast-conserving surgery?

For HR-positive/HER2-negative patients who can undergo breast-conserving surgery (BCS) but have a tumor size of 2–5 cm or 1–3 lymph node metastases, neoadjuvant chemotherapy (NAC) is still controversial.

Dandan Liu, Lidan Chang, Qian Hao… in Journal of Cancer Research and Clinical On… (2024)

Article

Plasma exosomes contain protein biomarkers valuable for the diagnosis of lung cancer

Accumulating evidence indicates that exosomal proteins are critical in diagnosing malignant tumors. To identify novel exosomal biomarkers for lung cancer diagnosis, we isolated plasma exosomes from 517 lung ca...

Zhiqiang Liu, Hong Huang, **g Ren, Tingting Song, Yinyun Ni… in Discover Oncology (2024)

Article

Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression

Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer. With studies demonstrating the potential of traditional C...

** Zhao, **ng-Bo He, **n-Yue Chen, Zhang-Long Li, Wen-Jia **ng… in Discover Oncology (2024)

Article

The later-line efficacy and safety of immune checkpoint inhibitors plus anlotinib in EGFR-mutant patients with EGFR-TKI-resistant NSCLC: a single-center retrospective study

Effective treatment after EGFR-TKI resistance is of great clinical concern. We aimed to investigate the efficacy and safety of anlotinib in combination with an anti-PD-1/PD-L1 antibody in later-line therapy fo...

**aoyan Yin, **nchao Liu, Fei Ren, **angjiao Meng in Cancer Immunology, Immunotherapy (2024)

Article

Codonopsis pilosula-derived glycopeptide dCP1 promotes the polarization of tumor-associated macrophage from M2-like to M1 phenotype

The majority of the immune cell population in the tumor microenvironment (TME) consists of tumor-associated macrophages (TAM), which are the main players in coordinating tumor-associated inflammation. TAM has ...

Hongxu Liu, Mao** Yao, Jiaoyan Ren in Cancer Immunology, Immunotherapy (2024)

Article

Camrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study

The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346...

Shengxiang Ren, Anwen **ong, Jia Yu, **cheng Wang… in Cancer Immunology, Immunotherapy (2024)

Article

Chemoradiotherapy versus surgery after neoadjuvant chemoimmunotherapy in patients with stage III NSCLC: a real-world multicenter retrospective study

The optimal treatment after neoadjuvant chemoimmunotherapy for patients with stage III non-small cell lung cancer (NSCLC) is unclear. This study aimed at comparing the efficacy and safety of chemoradiotherapy ...

Song Guan, Jifeng Sun, Yuan Wang, Sibei Han, Chen Chen… in Cancer Immunology, Immunotherapy (2024)

Article

Dual roles of HK3 in regulating the network between tumor cells and tumor-associated macrophages in neuroblastoma

Neuroblastoma (NB) is the most common and deadliest extracranial solid tumor in children. Targeting tumor-associated macrophages (TAMs) is a strategy for attenuating tumor-promoting states. The crosstalk betwe...

**n Wu, Tao Mi, Liming **, Chunnian Ren, **kui Wang… in Cancer Immunology, Immunotherapy (2024)

Article

Elucidating molecular mechanisms and therapeutic synergy: irreversible HER2-TKI plus T-Dxd for enhanced anti-HER2 treatment of gastric cancer

HER2-targeted therapies have improved the outcomes of HER2-positive gastric cancer (GC), yet resistance remains a challenge. We sought to explore the effects of reversible and irreversible HER2 tyrosine kinase...

Jiankun Liu, Tienian Zhu, Rui**g Zhao, Wenjun Ren, Fei Zhao, **gpu Liu in Gastric Cancer (2024)

Article

High core 1β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma

Core 1β1,3-galactosyltransferase 1 (C1GALT1) exhibits elevated expression in multiple cancers. The present study aimed to elucidate the clinical significance of C1GALT1 aberrant expression and its impact on ra...

Yong Chen, Yanyan Ji, Lin Shen, Ying Li… in Journal of Cancer Research and Clinical On… (2024)

Article

Safety and clinical efficacy of immune checkpoint inhibitors in advanced gastric cancer in the real world

To evaluate the clinical efficacy and safety of immune checkpoint inhibitors in patients with advanced gastric cancer in the real world.

Wen Hao, Wen**g Liu, Ruimin Chang, Mi Yang… in Journal of Cancer Research and Clinical On… (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)