107 Result(s)
within
English
Molecular Medicine
** Tokunaga
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Article
Scanning and transmission electron microscopy of human ejaculate spermatozoa with special reference to their abnormal forms
Spermatozoa from fertile and infertile human ejaculates were observed under the scanning electron microscope. A parallel study of sections was performed by transmission electron microscope.
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Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine
Oral administration of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) to hamsters at a concentration of 50-83 μg/ml in the drinking water resulted in a high incidence of tumours in the glandular stomach. Short-te...
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Scanning electron microscopy of the glomerular filtration membrane in the rat kidney
The rat kidney was perfused with saline and glutaraldehyde, treated with Murakami's tannin-osmium impregnation method, ethanol-freeze cracked and dried by the critical point method. Gold-palladium evaporated s...
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Genetic polymorphism of the complement C2 in Japanese
Genetic polymorphism of the second component of human complement (C2) was investigated in 521 unrelated healthy adult Japanese using isoelectric focusing in polyacrylamide gel followed by a specific hemolytic ...
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Polymorphism of properdin factor B in Japanese. Description of a rare variant and data of association with HLA and C2
Polymorphism of the properdin factor B (BF) was investigated using an agarose gel immunofixation electrophoresis in 487 unrelated healthy adult Japanese who were already typed for HLA-A,-B,-C, and C2. Besides ...
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Erratum
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Letter to the Editors
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Polymorphism of BF, C2, and GLO in Japanese patients with insulin-dependent diabetes mellitus: Confirmation of an increase of BF *FT
The distribution of phenotypes controlled by three HLA-linked loci BF, C2, and GLO has been studied in Japanese patients with insulin-dependent diabetes mellitus (IDDM). A slight but significant higher inciden...
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Further study on a BF silent allele
A family was found which indicated the existence of a silent allele (BF * QO) at the locus for complement factor B. Three generations with eight members were studied. Four individuals were considered to be hetero...
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No evidence for linkage between the loci for coagulation factor XIII-A and HLA
The linkage analysis between the locus for coagulation factor XIII-A (F13A) and HLA region genes (HLA-A,-C,-B) was performed. In males, the maximum of lod scores between F13A and HLA was 0.33 at θ=0.30, and in...
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Article
Demonstration of rod and cone photoreceptors in the lamprey retina by freeze-replication and immunofluorescence
In common with other cyclostomata, the Japanese river lamprey (Lampetra japonica) has a retina consisting of distinct types of photoreceptor cells called long and short photoreceptor cells. After freeze-fracture,...
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Demonstration by lectin cytochemistry of rod and cone photoreceptors in the lamprey retina
Lectin cytochemical analysis was undertaken to examine the distribution of glycoconjugates associated with the short and long photoreceptor cells in the lamprey retina. Concanavalin A bound preferentially to t...
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Stage-specific localization of cytoskeletal actin mRNA in murine seminiferous tubules and intestinal epithelia as demonstrated by in-situ hybridization
In-situ hybridization experiments have been performed using isoactin (β and γ)-specific riboprobes in various tissues of the rat and mouse. Distribution of the grains of actin mRNAs for both β and γ types was sim...
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Morphology of the granular hemocytes of the Japanese horseshoe crabTachypleus tridentatus and immunocytochemical localization of clotting factors and antimicrobial substances
The structure of hemocytes in the normal state and during blood coagulation, and the intracellular localization of three clotting factors and two antimicrobial factors were examined in the Japanese horseshoe crab
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Anti-lamprey retinal antibodies: immunohistochemistry on the retinas of several species of vertebrates
Two monoclonal antibodies, H16 and B11, which were raised against lamprey retinal homogenate, were found to react with both short and long photoreceptor outer segments. On Western blotting of the retinal homog...
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A new strategy of gene trap** in ES cells using 3'RACE
“Gene trap**” in embryonic stem (ES) cells is a novel approach to identify a series of genes in mammals concomitant with the production of the corresponding mutant mice. However, this approach is currently u...
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Extensive polymorphism of ABO blood group gene: three major lineages of the alleles for the common ABO phenotypes
Polymorphism of the ABO blood group gene was investigated in 262 healthy Japanese donors by a polymerase chain reactions-single-strand conformation polymorphism (PCR-SSCP) method, and 13 different alleles were...
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Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor–1 (PAI–1) levels was investigated in humans and animal...
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Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells
Although case-oriented evidence for an association of Epstein-Barr virus (EBV) with gastric carcinoma has been accumulating recently, the interaction(s) between EBV and gastric epithelial cells is/are largely ...
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P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo
We examined whether the increased expression of P-glycoprotein (P-gp) encoded by the human multidrug resistance gene MDR1 is related to the acquired multidrug resistance of lung cancer in vivo. We estimated th...
