Cancer Drug Discovery
Science and History
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Article
Metastable hexagonal close-packed palladium hydride in liquid cell TEM
Metastable phases—kinetically favoured structures—are ubiquitous in nature1,2. Rather than forming thermodynamically stable ground-state structures, crystals grown from high-energy precursors often initially adop...
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Open AccessGenomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes
Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their sa...
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Article
Treatment of periorbital wrinkles using multipolar fractional radiofrequency in Korean patients
A limited number of studies have evaluated the efficacy and safety of electrode pin fractional radiofrequency (FRF) for periorbital wrinkle treatment in Asian patients, but none have measured noninvasive metho...
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Article
In situ synthesis of chemically bonded NaTi2(PO4)3/rGO 2D nanocomposite for high-rate sodium-ion batteries
A phase-pure NaTi2(PO4)3/reduced graphene oxide (rGO) nanocomposite was prepared using a microwave-assisted one-pot method and subsequent heat treatment. The well-crystallized NaTi2(PO4)3 nanoparticles (30–40 nm)...
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Book
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Chronology of Anticancer Drug Development
Cancer was not recognized as a major cause of death in western industrialized countries until the nineteenth century, but the cancer-related mortality increased rapidly after the decrease in lethal infectious ...
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Advancements in Bioscience and New Cancer Drugs
The parallel development of life science and cancer treatment after the introduction of the cell theory in 1838 can be briefly summarized as shown in Fig. 11.1. In the mid-1850s, cancer entered the field of sc...
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Advancements in Life Sciences and Characteristic Features of Cancer Cells
Advances in modern life sciences have primarily focused on cellular research because of the “Cell Theory” (Schleiden and Schwann 1838), which defines the cell as the basic unit of all organisms. Since cells ar...
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Antimetabolic Anticancer Drugs
Antimetabolic drugs bind to a specific enzyme and prevent normal metabolites from interacting with the enzymes, leading to inhibition of a specific metabolic pathway. Especially, the antimetabolic anticancer d...
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Immunotherapeutic Anticancer Drugs and Other Miscellaneous Anticancer Drugs
Immunotherapeutic anticancer agents eliminate cancer cells by acting on the immune system and activating the immune response against cancer cells. This class of drugs includes cytokines such as INFγ and IL2, n...
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Molecular Targeted Anticancer Drugs
From the middle of the 1960s, combination chemotherapy was at the center of chemotherapy for cancer. Following successful treatment of various hematologic malignancies through combination chemotherapy, signifi...
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Advancement of the Science and History of Cancer and Anticancer Drugs
Schleiden and Schwann first reported the Cell Theory in 1838, and Remak and R. C. Virchow advocated this theory for cancer in the mid-1850s. They named cancer “neoplasm,” which was defined as a new mass of cel...
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Alkylating Anticancer Drugs
Alkylating agents are the first chemotherapeutic anticancer agents developed, and account for the largest drug group among conventional cytotoxic chemotherapeutics. This class is largely divided into three sub...
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Natural Product Anticancer Drugs
Natural product anticancer drugs that are used clinically include compounds isolated from plants such as the vinca alkaloids, taxane/taxane analogues, podophyllotoxin derivatives, and camptothecin derivatives,...
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Complications of Anticancer Drugs and Their Management
Anticancer therapy targets actively growing and dividing cells. Because of this characteristic, anticancer drugs assaults not only cancer cells but also normally proliferating cells such as blood cells, mucosa...
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Hormonal Anticancer Drugs
Paul Ehrlich, a pioneer in chemotherapy, experienced many failures while develo** anticancer chemotherapy due to the indiscriminate toxicity of chemotherapy drugs. In 1915, based on his experience, he stress...
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Article
Leiomyosarcoma: investigation of prognostic factors for risk-stratification model
We performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors.
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Article
Benzo(a)pyrene represses melanogenesis in B16F10 mouse melanoma cells
Benzo(a)pyrene (BaP) is a chemically based polycyclic aromatic hydrocarbon (PAH) that is readily absorbed by the skin. BaP is metabolized to BaP-diol-epoxide by cytochromes P-450 1A1/2 (CYP1A1/2) and cytochrom...
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Open AccessAssessment of airflow and microclimate for the running wear jacket with slits using CFD simulation
This study was performed to estimate the exchange of air (ventilation) and temperature distribution in the cylinder that simulated human body. Simulation simplified the human body wearing the running wear jack...
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Article
Prognostic Value of Mucinous Histology Depends on Microsatellite Instability Status in Patients with Stage III Colon Cancer Treated with Adjuvant FOLFOX Chemotherapy: A Retrospective Cohort Study
The close association between mucinous histology and microsatellite instability (MSI) may have hindered the evaluation of prognostic significance of mucinous histology. The aim of this retrospective study was ...
