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Article
Open AccessRapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network
The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections. Microbial infections are a major healthcare issue worldwide, as these widespread diseases...
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Article
Open AccessRestoration of FVIII expression by targeted gene insertion in the FVIII locus in hemophilia A patient-derived iPSCs
Target-specific genome editing, using engineered nucleases zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and type II clustered regularly interspaced short palindromic repe...
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Article
Modeling and correction of structural variations in patient-derived iPSCs using CRISPR/Cas9
This protocol extends the use of genome editing technology to the modeling or correction of large chromosomal rearrangements and short nucleotide repeat expansions. The authors use the CRISPR/Cas system to edi...
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Article
Open AccessGenome-editing technologies for gene correction of hemophilia
Hemophilia is caused by various mutations in blood coagulation factor genes, including factor VIII (FVIII) and factor IX (FIX), that encode key proteins in the blood clotting pathway. Although the addition of the...
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Article
High-Speed, High-Sensitivity Polyimide Humidity Sensors Based on MEMS Microhotplates
Polyimides thin films, which are the most commonly used group of sensing materials for capacitive humidity sensors, were cured locally using MEMS microhotplates. The polyimide locally cured at temperature over...
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Article
Observations of Forsythia koreana methanol extract on mast cell-mediated allergic reactions in experimental models
To explore effects of Forsythia koreana methanol extract (FKME) on mast cell-mediated allergic and inflammatory properties, the effect of FKME was evaluated on compound 48/80-induced systemic anaphylaxis, ear swe...
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Article
Characteristic of grain oriented (Bi0.5Na0.5)TiO3-BaTiO3 ceramics
Dielectric and piezoelectric properties of grain oriented (Bi0.5Na0.5)TiO3-BaTiO3 ceramics were investigated in a process that the templated grain growth and hot pressing methods were employed. A ceramic composit...
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Article
Open AccessTanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3
Tanshinone II-A is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. W...
