50 Result(s)
within
Biomedicine
** Dong-ming
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Chapter
Characterization of Chinese Hamster Cell Lines That are X-Ray-Sensitive, Impaired in DNA Double-Strand Break Repair and Defective for V(D)J Recombination
DNA double-strand breaks (DSB) can fornn spontaneously or be induced experimentally via ionizing radiation (IR). DSB are extremely toxic and all living organisms have developed repair mechanisms to cope with t...
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Article
Cardiac glycosides induce resistance to tubulin-dependent anticancer drugs in androgen-independent human prostate cancer
Due to high prevalence and mortality and the lack of effective therapies, prostate cancer is one of the most crucial health problems in men. Drug resistance aggravates the situation, not only in human prostate...
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Article
Open AccessStage-specific changes in fetal thymocyte proliferation during the CD4-8- to CD4+8+ transition in wild type, Rag1-/-, and Hoxa3,Pax1 mutant mice
The function of the thymic microenvironment is to promote thymocyte maturation, in part via regulation of thymocyte proliferation and cell death. Defects in fetal thymic epithelial cell (TEC) development and f...
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A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation
Thymic epithelial cells (TECs) are required for T cell maturation within the thymus. In the nude (Foxn1nu/nu) mouse, TECs fail to differentiate. We have generated a hypomorphic allele called Foxn1Δ, from which an...
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Article
Experimental investigation of external explosion in the venting process
Experimental investigations were conducted on the process of combustion and explosion vent in a 200 mm (diameter)×400 mm (length) vertical cylindrical vessel. When CH4-air mixture gases were used and the vent dia...
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Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol
To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO).
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Anthraquinone pharmacokinetics in **exin decoction and the different combinations of its constituent herbs
**exin decoction (XXD), a classical pyretolytic formulation, is composed ofRhei rhizoma (DH)Radix scutellaria (HQ) andCoptis chinensis (HL), and commonly used in the clinical setting. The aim of this study was to...
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Suppression of inflammatory cytokine production and oxidative stress by CO-releasing molecules—liberated CO in the small intestine of thermally-injured mice
To determine whether carbon monoxide (CO)-releasing molecules-liberated CO suppress inflammatory cytokine production and oxidative stress in the small intestine of burnt mice.
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Selection pressure on Haemagglutinin genes of H9N2 influenza viruses from different hosts
Positive selection and differential selective pressure analyses were carried out to study Haemagglutinin (HA) genes of H9N2 influenza viruses from different hosts in this paper. Results showed that, although m...
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Positive selection analysis of VP1 Genes of worldwide human enterovirus 71 viruses
Human enterovirus 71 viruses have been long circulating throughout the world. In this study, we performed a positive selection analysis of the VP1 genes of capsid proteins from Enterovirus 71 viruses. Our resu...
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Article
Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory
The aim of this study was to investigate the cognition-enhancing activity and underlying mechanisms of a triterpenoid saponin (polygalasaponin XXXII, PGS32) isolated from the roots of Polygala tenuifolia Willd.
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MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ
Macrophages (Mφ) are prominent components of solid tumors and exhibit distinct phenotypes in different microenvironments. We have recently found that tumors can alter the normal developmental process of Mφ to ...
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Expression of the apoptosis-related proteins caspase-3 and NF-κB in the hippocampus of Tg2576 mice
To investigate the relations between neuroapoptosis and the onset and development of Alzheimer’s disease (AD), especially the role of NF-κB in the regulation of neuroapoptosis.
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The Synaptic Remodeling Between Regenerated Perforant Pathway and Granule Cells in Slice Culture
In order to understand the synaptic remodeling in the course of axonal regeneration, the synaptic remodeling of the perforant path in hippocampus was investigated in the present study with entorhino-hippocampa...
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Article
Open AccessMethylation status of DDIT3 gene in Chronic Myeloid Leukemia
DNA-damage-inducible transcript 3 (DDIT3), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes of TSGs are recently re...
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Open AccessGTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies
GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. However, the ...
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Article
Effects of Mutant Huntingtin on mGluR5-Mediated Dual Signaling Pathways: Implications for Therapeutic Interventions
Glutamate excitotoxicity is thought to play an important role in Huntington’s disease (HD), which is caused by a polyglutamine expansion in the HD protein huntingtin (htt). Overactivation of group I metabotrop...
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Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium
Expansion of thymic epithelial cysts represents disruption of an organized three-dimensional (3D) thymic epithelial cell (TEC) meshwork, which is crucial for T-lymphocyte development. Although the FoxN1-null muta...
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Protective effect of Bu-7, a flavonoid extracted from Clausena lansium, against rotenone injury in PC12 cells
To investigate the protective effect and underlying mechanisms of Bu-7, a flavonoid isolated from the leaves of Clausena lansium, against rotenone-induced injury in PC12 cells.
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Article
Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation
To investigate the effect and underlying mechanisms of polygalasaponin F (PGSF), a triterpenoid saponin isolated from Polygala japonica, on long-term potentiation (LTP) in hippocampus dentate gyrus (DG) of anesth...
