2,488 Result(s)
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Open AccessPromoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer
In tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly compromised by drug resistance. Consequently, finding an effective so...
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ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the olfactory bulb (OB) ...
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Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction
Reforming carbon dioxide (CO2) into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply challenges. The recombination of photocarriers r...
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Advance on Chinese Medicine for Hypertensive Renal Damage: Focus on the Complex Molecular Mechanisms
Hypertensive renal damage (HRD) is a major cause of end-stage renal disease. Among the causes of end-stage renal disease, HRD accounts for nearly 34% of the total number of cases. Antihypertensive treatment is...
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Chinese Medicine for Treatment of COVID-19: A Review of Potential Pharmacological Components and Mechanisms
Coronavirus disease 2019 (COVID-19) is an acute infectious respiratory disease that has been prevalent since December 2019. Chinese medicine (CM) has demonstrated its unique advantages in the fight against COV...
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Host preference and mortality caused by the parasitoid Sclerodermus guani on different cerambycid species
Parasitoids of wood borers and bark beetles rarely encounter different host species simultaneously in nature, so whether they exhibit any preferences for particular species, and the relative suitability of dif...
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Event-triggered Hybrid Force Feedback Architecture With Tank-based Stabilization Method for Complicated Bilateral Teleoperation Tasks
Bilateral teleoperation with force feedback allows the operators to apply their skills to accomplish challenging tasks safely. Most teleoperation bilateral systems are designed for single interaction scenarios...
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Salvage haploidentical transplantation for graft failure after first haploidentical allogeneic stem cell transplantation: an updated experience
Graft failure is a fatal complication following allogeneic stem cell transplantation where a second transplantation is usually required for salvage. However, there are no recommended regimens for second transp...
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Nonsingular Fixed-time Fault-tolerant Sliding Mode Control of Robot Manipulator With Disturbance Observer
This paper presents a nonsingular sliding mode fault-tolerant control method with fixed-time convergence for a class of robot manipulators with uncertainties, external disturbances, and actuator failures. We e...
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Testing Linearity in Functional Partially Linear Models
For the functional partially linear models including flexible nonparametric part and functional linear part, the estimators of the nonlinear function and the slope function have been studied in existing litera...
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Wave interaction for a generalized higher-dimensional Boussinesq equation describing the nonlinear Rossby waves
Based on an algebraically Rossby solitary waves evolution model, namely an extended (2+1)-dimensional Boussinesq equation, we firstly introduced a special transformation and utilized the Hirota method, which e...
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Open AccessDeep learning model for the prediction of all-cause mortality among long term care people in China: a prospective cohort study
This study aimed to develop a deep learning model to predict the risk stratification of all-cause death for older people with disability, providing guidance for long-term care plans. Based on the government-le...
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Open AccessParental Reflective Capacities: A Sco** Review of Mindful Parenting and Parental Reflective Functioning
Two key parental reflective capacities—mindful parenting (MP) and parental reflective functioning (PRF) — have been shown to promote healthy parent-child relationships through parents’ increased sensitivity an...
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Open AccessDUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...
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Open AccessThe circular RNA hsa_circ_0045800 serves as a favorable biomarker in pathogenesis of sjögren's syndrome
Circular RNAs (circRNAs) play various roles in the development of many autoimmune diseases. However, their expression profiles and specific function in Sjögren's Syndrome remains largely unknown.
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Open AccessDe novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation
The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovar...
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Open AccessCounterion docking: a general approach to reducing energetic disorder in doped polymeric semiconductors
Molecular do** plays an important role in controlling the carrier concentration of organic semiconductors. However, the introduction of dopant counterions often results in increased energetic disorder and tr...
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Self-pressurizing nanoscale capsule catalysts for CO2 electroreduction to acetate or propanol
The selective one-step CO2 electroreduction reaction (CO2RR) to acetate and propanol has garnered intense interest. Here we report the design of self-pressurizing nanoscale capsule catalysts for the CO2RR. A high...
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Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries
After traumatic injury in pregnant women, providing timely and appropriate management for high-risk patients is crucial for both pregnant women and fetuses. This study aimed to identify risk factors that predi...
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Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass ...
