2,328 Result(s)
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Life Sciences
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Article
Biotic homogenisation and differentiation of fish assemblages in subtropical agroecosystems located in southern China
Anthropogenic land use has caused a major crisis to the biodiversity of stream fishes in recent decades, especially with regard to biotic homogenisation. Understanding the response of stream fishes to anthropo...
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Phylogeny of Neolissochilus and studies on intergeneric kinship geography of Cyprinidae
Accurate species delimitation and phylogenetic reconstruction are vital to understand biodiversity assessments, conservation management, evolutionary patterns, evolutionary processes, and historical biogeograp...
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Combined Analysis of Transcriptome and Small RNA Sequencing Reveals the Mechanism of UV-B-promoted Flavonoid Biosynthesis in Ginkgo biloba
Flavonoids are the most abundant medicinal ingredients in Ginkgo biloba L. leaf extract (GBE), which is an important industrial raw material for the treatment of cardiovascular and cerebrovascular diseases. Our p...
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COVID-19 drug discovery and treatment options
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and mortality, and serious social and economic disruptio...
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The nematode-trap** fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors
The ability to sense prey-derived cues is essential for predatory lifestyles. Under low-nutrient conditions, Arthrobotrys oligospora and other nematode-trap** fungi develop dedicated structures for nematode cap...
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Open AccessThe global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which are classified into Ere-type and the less studied Est-type. In...
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Open AccessGenome-wide development of simple sequence repeats markers and genetic diversity analysis of chayote
Chayote is a high economic crop in the Cucurbitaceae family, playing an important role in food production, disease treatment and the production of degradable materials in industries. Due to the harsh environme...
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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Epigenetic regulators have a crucial effect on gene expression based on their manipulation of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well-established hallmark in transcription...
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Effects of the Concentrations of Nitrogen Supplied From Both or One-Half of the Dual-Root System on the Nitrogen Fixation of Soybean Nodules and the Distribution of Absorbed Nitrogen From Roots
This study aimed to investigate the effects of the different concentrations of ammonium or nitrate supplied from both or one-half of the dual-root system on the nitrogen fixation of soybean nodules and the dis...
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Open AccessProbing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy
Chromatin organization and dynamics play important roles in governing the regulation of nuclear processes of biological cells. However, due to the constant diffusive motion of chromatin, examining chromatin na...
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Denitrificimonas halotolerans sp. nov., a novel species isolated from UASB sludge treating landfill leachate
A Gram-stain-negative, facultative anaerobe, rod-shaped strain JX-1T was isolated from UASB sludge treating landfill leachate in Wuhan, China. The isolate is capable of growing under conditions of pH 6.0–11.0 (op...
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Histidine modified Fe3O4 nanoparticles improving the ethanol yield and tolerance of Saccharomyces cerevisiae
Saccharomyces cerevisiae, the primary microorganism involved in ethanol production, is hindered by the accumulation of ethanol, leading to reduced ethanol production. In this study, we employed histidine-modified...
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Open AccessCXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity
The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that d...
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Long intergenic non-protein coding RNA 1436 accelerates cell proliferation, migration and adhesion properties of the MUM-2B cell line via microRNA-513a-5p/CUG Triplet repeat-binding protein 1 axis to activate the phosphatidylinositol 3-kinase/Akt signaling pathway
Long intergenic non-protein coding RNA 1436 (LINC01436) has been reported as a critical regulator of tumor occurrence, but the association between LINC01436 and choroidal melanoma (CM) has hardly been explored...
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Open AccessConjoint analysis of physio-biochemical, transcriptomic, and metabolomic reveals the response characteristics of solanum nigrum L. to cadmium stress
Cadmium (Cd) is a nonessential element in plants and has adverse effects on the growth and development of plants. However, the molecular mechanisms of Cd phytotoxicity, tolerance and accumulation in hyperaccum...
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Open AccessSpliceAPP: an interactive web server to predict splicing errors arising from human mutations
Splicing variants are a major class of pathogenic mutations, with their severity equivalent to nonsense mutations. However, redundant and degenerate splicing signals hinder functional assessments of sequence v...
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Open AccessRegulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth
Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia are necessary to support GNP proliferation, the exact molecul...
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Open AccessA novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma
The oncogenic potential of chromosome 8q22 copy number gain in liver cancer remains to be depicted. Here, we report that ZNF706, encoded by a gene mapped to chromosome 8q22, is a C2H2-type zinc finger protein....
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Open AccessUCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1
The proliferation of porcine ovarian granulosa cells (GCs) is essential to follicular development and the ubiquitin–proteasome system is necessary for maintaining cell cycle homeostasis. Previous studies found...
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Open AccessCDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells
Paraptosis is a programmed cell death characterized by cytoplasmic vacuolation, which has been explored as an alternative method for cancer treatment and is associated with cancer resistance. However, the mech...
