66 Result(s)

Article

Novel Coumarins Derivatives for A. baumannii Lung Infection Developed by High-Throughput Screening and Reinforcement Learning

With the increasing resistance of Acinetobacter baumannii (A. baumannii) to antibiotics, researchers have turned their attention to the development of new antimicrobial agents. Among them, coumarin-based heterocy...

**g Li, Zhou Lu, Liuchang Wang, Huiqing Shi… in Journal of Neuroimmune Pharmacology (2024)

Article

Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities

HER2-positive (HER2⁺) metastatic breast cancer (mBC) is highly aggressive and a major threat to human health. Despite the significant improvement in patients’ prognosis given the drug development efforts during t...

Ya-ting Zhou, Jia-hui Chu, Shu-han Zhao, Ge-li Li, Zi-yi Fu… in Acta Pharmacologica Sinica (2024)

Article

Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway

Shi-feng Chu, Zhao Zhang, **n Zhou, Wen-bin He, Chen Chen… in Acta Pharmacologica Sinica (2024)

Article

Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice

Aberrant activation of complement cascades plays an important role in the progress of neurological disorders. Complement C3, the central complement component, has been implicated in synaptic loss and cognitive...

Ying Chen, John Man-Tak Chu, Gordon Tin-Chun Wong… in Journal of Neuroimmune Pharmacology (2024)

Article

Author Correction: Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, **ao-lin Wang… in Acta Pharmacologica Sinica (2023)

Article

Correction to: Neferine Inhibits Expression of Inflammatory Mediators and Matrix Degrading Enzymes in IL-1β-Treated Rat Chondrocytes via Suppressing MAPK and NF-κB Signaling Pathways

Bowei Ni, **aojian Huang, Yang **, Zekai Mao, **angyu Chu, Rui Zhang… in Inflammation (2023)

Article

Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation

The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related a...

Xue Cao, Yanhong Li, Yubin Luo, Tianshu Chu, Hang Yang, Ji Wen… in Journal of Inflammation (2023)

Article

Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα

miRNAs play a crucial role in regulating immune responses. However, the effect of miR-124-3p on type 2 inflammation in allergic rhinitis (AR) is unclear. We aimed to study the immune regulation of miR-124-3p i...

Qian Liu, Yang Shen, Yifang **ao, Hong **ang, Ling Chu… in Inflammation Research (2022)

Article

Emerging novel approaches to drug research and diagnosis of Parkinson’s disease

Xue-chu Zhen, Hong-Yuan Chu in Acta Pharmacologica Sinica (2020)

Article

Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice

Stroke is a disease that mainly affects the elderly. Since the age-related differences in stroke have not been well studied, modeling stroke in aged animals is clinically more relevant. The inflammatory respon...

Shou-cai Zhao, Chun Wang, Heng Xu, Wen-qian Wu, Zhao-hu Chu… in Acta Pharmacologica Sinica (2017)

Article

Protective Effects of Neural Crest-Derived Stem Cell-Conditioned Media against Ischemia-Reperfusion-Induced Lung Injury in Rats

Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs)...

Chung-Kan Peng, Shu-Yu Wu, Shih-En Tang, Min-Hui Li, Shih-Shiuan Lin… in Inflammation (2017)

Article

Regulation of microglial activation in stroke

When ischemic stroke occurs, oxygen and energy depletion triggers a cascade of events, including inflammatory responses, glutamate excitotoxicity, oxidative stress, and apoptosis that result in a profound brai...

Shou-cai Zhao, Ling-song Ma, Zhao-hu Chu, Heng Xu… in Acta Pharmacologica Sinica (2017)

Article

Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro

Accumulation of α-synuclein (α-syn) in the brain is a characteristic of Parkinson's disease (PD). In this study, we investigated whether treatment with tunicamycin, an endoplasmic reticulum (ER) stress inducer...

Zheng Mou, Yu-he Yuan, Yu-xia Lou, Yang Heng, Ju-yang Huang… in Acta Pharmacologica Sinica (2016)

Article

Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3

To examine the biological consequences and demographic factors that might affect the pharmacokinetics of vitamin D3 after a single high dose intervention in a young Chinese population with vitamin D insufficie...

Pei-zhan Chen, Mian Li, **ao-hua Duan, **g-ying Jia… in Acta Pharmacologica Sinica (2016)

Article

RAD18 polymorphisms are associated with platinum-based chemotherapy toxicity in Chinese patients with non-small cell lung cancer

Although targeted therapy is very efficient for lung cancer, traditional platinum-based chemotherapies are still the principal strategy in the absence of positive biomarkers. The aim of the present study is to...

Tian-qing Chu, Rong Li, Min-hua Shao, Jun-yi Ye, Bao-hui Han in Acta Pharmacologica Sinica (2016)

Article

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

It is general believed that mitochondrial dysfunction and oxidative stress play critical roles in the pathology of Parkinson's disease (PD). Dihydromyricetin (DHM), a natural flavonoid extracted from Ampelopsis g...

Zhao-xiang Ren, Ya-fei Zhao, Ting Cao, Xue-chu Zhen in Acta Pharmacologica Sinica (2016)

Article

Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca²⁺-dependent myosin phosphorylation

Postoperative ileus (POI) is a postoperative dysmotility disorder of gastrointestinal tract, which remains one of the most perplexing problems in medicine. In the present study we investigated the effects of h...

Yong-jian **ong, Hong-wei Chu, Yuan Lin, Fang Han, Ya-chan Li… in Acta Pharmacologica Sinica (2016)

Article

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

Recent studies show that the extract of a Chinese herb Polygalae Radix exerts cognition-enhancing actions in rats and humans. The aim of this study was to characterize the pharmacological profiles of active co...

Heng Zhou, Wei Xue, Shi-feng Chu, Zhen-zhen Wang… in Acta Pharmacologica Sinica (2016)

Article

Resolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement, Immunoglobulin, TLR4, and Inflammatory Factors in Rats

Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively affects the prognosis of many lung diseases. The aim of this study is to determine the effects of RvD1 on LIRI and t...

Qifeng Zhao, Ji Wu, Zhiyong Lin, Qingwang Hua, Weixi Zhang, Le** Ye… in Inflammation (2016)

Article

20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway

Our preliminary study shows that a bibenzyl compound isolated from Gastrodia elata, 2-[4-hydroxy-3-(4-hydroxybenzyl)benzyl]-4-(4-hydroxybenzyl)phenol (designated 20C), protects PC12 cells against H₂O₂-induced inj...

Ju-yang Huang, Yu-he Yuan, Jia-qing Yan, Ya-nan Wang… in Acta Pharmacologica Sinica (2016)