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Autotaxin Inhibition Reduces Post‐Ischemic Myocardial Inflammation via Epigenetic Gene Modifications
Myocardial infarction (MI) triggers a complex inflammatory response that is essential for cardiac repair but can also lead to adverse outcomes if...
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Possible Drug Repurposing and Accelerated Wound Healing
PurposeHealing of a wound is a multifaceted process that involves several factors to be considered for proper completion. Improper healing of wounds...
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Applications of extraembryonic tissue-derived cells in vascular tissue regeneration
Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and develo** new therapeutic approaches for heart...
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Antibacterial, Antioxidant, and Healing Potential of Wound Dressings Utilizing Cranberry Extract in Combination with Methacrylated Polyvinyl Alcohol and Methacrylated Sericin
PurposeHydrogels, due to their hydrophilic nature and tunable properties, have emerged as promising materials for wound dressings. Notably, the...
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Extracellular Microvesicles vs. Mitochondria: Competing for the Top Spot in Cardiovascular Regenerative Medicine
Regenerative medicine aims to restore, replace, and regenerate human cells, tissues, and organs. Despite significant advancements, many cell therapy...
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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive...
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Extracellular Vesicles from Adipose Tissue-Derived Stromal Cells Stimulate Angiogenesis in a Scaffold-Dependent Fashion
Background:The extracellular vesicles (EVs) secreted by adipose tissue-derived stromal cells (ASC) are microenvironment modulators in tissue...
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Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia
Haematopoiesis within the bone marrow (BM) represents a complex and dynamic process intricately regulated by neural signaling pathways. This delicate...
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IRTKS Elevation in Patients with Colon Cancer and the Curative Influences of Hamsc Secretome on Polarity and Invasion of HT-29 Colon Cancer Cells
PurposeColon cancer is a major contributor (fifth one) to cancer-related deaths in the world. For the unique characteristics of stem cells, stem...
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Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation
BackgroundSkeletal Stem Cells (SSCs) are required for skeletal development, homeostasis, and repair. The perspective of their wide application in...
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Preclinical Therapeutic Efficacy of Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stromal/Stem Cells in Diabetic Wounds: a Systematic Review and Meta-Analysis
Extracellular vesicles isolated from adipose tissue-derived mesenchymal stromal/stem cells (ADSC-EVs) have demonstrated promising potential in wound...
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Essential role of p21Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response
BackgroundTraumatic Brain Injury (TBI) represents one of the main causes of brain damage in young people and the elderly population with a very high...
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Decoding cellular plasticity and niche regulation of limbal stem cells during corneal wound healing
BackgroundDysfunction or deficiency of corneal epithelium results in vision impairment or blindness in severe cases. The rapid and effective...
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Comparative effectiveness of mesenchymal stem cell versus bone-marrow mononuclear cell transplantation in heart failure: a meta-analysis of randomized controlled trials
BackgroundThere is no clear evidence on the comparative effectiveness of bone-marrow mononuclear cell (BMMNC) vs. mesenchymal stromal cell (MSC) stem...
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Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease
BackgroundNeural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless,...
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New advances of NG2-expressing cell subset in marrow mesenchymal stem cells as novel therapeutic tools for liver fibrosis/cirrhosis
BackgroundBone marrow-derived mesenchymal stem cell ( BM MSC)-based therapy has become a major focus for treating liver fibrosis/cirrhosis. However,...
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Distraction force promotes the osteogenic differentiation of Gli1+ cells in facial sutures via primary cilia-mediated Hedgehog signaling pathway
BackgroundTrans-sutural distraction osteogenesis (TSDO) involves the application of distraction force to facial sutures to stimulate osteogenesis....
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Effect of Post-transplant Dietary Restriction on Hematopoietic Reconstitution and Maintenance of Reconstitution Capacity of Hematopoietic Stem Cells
Hematopoietic cell transplantation (HCT) is an important therapy for many hematological malignancies as well as some non-malignant diseases....
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Pancreatic Differentiation of Oral Minor Salivary Gland Stem Cells
IntroductionStem cells from various sources including major salivary glands have been used to establish pancreatic differentiation in an attempt to...
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In vitro and in vivo dissolution of biocompatible S59 glass scaffolds
Fabrication of porous tissue-engineering scaffolds from bioactive glasses (BAG) is complicated by the tendency of BAG compositions to crystallize in...
