134 Result(s)
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Living Reference Work Entry In depth
A Global Library of Underwater Biological Sounds (GLUBS): An Online Platform with Multiple Passive Acoustic Monitoring Applications
Aquatic ecosystems contain some of the world’s most diverse environments, and their soundscapes are often teeming with sounds from a wealth of biological sources. Passive acoustic monitoring (PAM) is an increa...
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Living Reference Work Entry In depth
The Role of Innate T Cells in Cancer
Innate T cells, comprising invariant natural killer T (iNKT) cells, gamma delta T (γδ T) cells, and mucosal-associated invariant T (MAIT) cells, constitute a vital component of the immune system, playing a cen...
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Living Reference Work Entry In depth
Evaluation of Metabolism-Dependent Drug Toxicity
Drug metabolism is well-established to play key roles in drug toxicity. Drug toxicity can be enhanced via biotransformation of a parent drug to metabolites with a higher toxicity potential, a process known as ...
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Reference Work Entry In depth
Genetic and Epigenetic Biomarkers Related to 2-Oxoglutarate/Fe(II)-Dependent Oxygenases and Implications for Disease and Toxicology
Biomarkers are important in investigating relationships among human biology, disease, environmental exposure, and toxicology. Genetic and epigenetic biomarkers, particularly the alkylated DNA and RNA, widely e...
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Living Reference Work Entry In depth
Soundscape Characterization in Chedabucto Bay on the Atlantic Coast of Canada, 2019–2021
Fisheries and Oceans Canada’s Coastal Acoustic Monitoring Project aims to better understand the underwater soundscape at coastal sites off Nova Scotia, Canada. Researchers began deploying passive acoustic moni...
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Reference Work Entry In depth
LC-MS-Based Metabolomics in the Identification of Biomarkers Pertaining to Drug Toxicity: A New Narrative
The evaluation of adverse drug effects is essential for drug approval and clinical therapy. Safe and reliable biomarkers play important roles in the prediction, detection, and management of drug-induced toxici...
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Living Reference Work Entry In depth
Flow Cytometry in the Diagnosis of Hematological Neoplasms and Other Cancers
Flow cytometry (FCM) is a powerful technology that can provide rapid multiparameter analysis of single cells. With the significant improvement in instrumentation and reagents during the past several decades, m...
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Reference Work Entry In depth
Doxorubicin Cardiotoxicity: Preclinical and Clinical Circulating Protein Markers
Cardiotoxicity remains one of the major threats to cancer patients treated with the potent anticancer drug doxorubicin. It has become a significant challenge in the posttreatment management of the growing popu...
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Reference Work Entry In depth
Circulating TGF-β1 Levels: Linking Muscle and Trauma
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional growth factor that plays a key role in a variety of human tissues. Three TGF-β1 target cell types are of particular relevance to muscle trauma, i...
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Living Reference Work Entry In depth
The Role of Exosomes in Tumor Metastasis
Exosomes, extracellular vesicles featuring phospholipid bilayers, play essential roles in cell–cell communication; tumor microenvironment (TME) remodeling (e.g., through cancer-associated fibroblast synthesis ...
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Reference Work Entry In depth
Murine Embryonic Stem Cells as Platform for Toxicity Studies: Use of Human Survivin Promoter with Green Fluorescent Protein Reporter for High-Throughput Screening
Embryonic and fetal development is a complicated process regulated by many signaling pathways and transcriptional factors that can be negatively impacted by drug or chemical exposure during pregnancy. It is ur...
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Reference Work Entry In depth
Prognostic Biomarkers to Predict Outcomes in Trauma
Traumatic injury accounts for significant morbidity and mortality across all age groups. Unlike other diseases, the onset of injury is known and therefore trauma is well poised as an ideal disease entity for t...
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Living Reference Work Entry In depth
Photoimmunotherapy for Cancer Treatment
Cancer, as one of the diseases with high mortality rates in the world, has received enormous attention from people. Conventional therapeutic approaches cannot satisfy the need for unacceptable side effects, tu...
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Reference Work Entry In depth
Metabolomics Profiling of Di-(2-propylheptyl) Phthalate (DPHP) Biotransformation Products as Exposure Markers: Analytical Strategy and Application
Phthalates are widely used in the manufacture of plastics and personal care products, and humans are easily exposed to phthalates through the usage of these products. Phthalates and di-(2-propylheptyl) phthala...
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Reference Work Entry In depth
Pain
Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions encountered from the external or internal environment. Pain can be ...
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Living Reference Work Entry In depth
Genetic and Epigenetic Biomarkers Related to 2-Oxoglutarate/Fe(II)-Dependent Oxygenases and Implications for Disease and Toxicology
Biomarkers are important in investigating relationships among human biology, disease, environmental exposure, and toxicology. Genetic and epigenetic biomarkers, particularly the alkylated DNA and RNA, widely ...
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Living Reference Work Entry In depth
A Review of Neurotoxicities Associated with Immune Checkpoint Inhibitors
The last decade has seen an exponential rise in the use of immune checkpoint inhibitors (ICIs). The use of ICIs has given new hope in cancer treatment. At the same time, there are unique side effects related t...
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Reference Work Entry In depth
Auditory Memory
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Reference Work Entry In depth
Biophysical Models of Olfactory Mitral and Granule Cells
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Living Reference Work Entry In depth
Circulating TGF-β1 Levels: Linking Muscle and Trauma
Transforming growth factor-beta 1 (TGF-β1) is a multifunctional growth factor that plays a key role in a variety of human tissues. Three TGF-β1 target cell types are of particular relevance to muscle trauma, i...
