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    Protocol

    Quantitative Systems Toxicology and Drug Development: The DILIsym Experience

    DILIsym® is a Quantitative Systems Toxicology (QST) model that has been developed over the last decade by a public-private partnership to predict the liver safety liability in new drug candidates. DILIsym integra...

    Paul B. Watkins in Systems Medicine (2022)

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    Protocol

    An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury

    Drug-induced liver injury (DILI) is one of the primary reasons why a new drug candidate may fail during development. To address this challenge, a mathematical representation, DILIsym®, has been developed as a ...

    Christina Battista, Brett A. Howell, Scott Q. Siler… in Drug-Induced Liver Toxicity (2018)