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    Protocol

    A Brief History of the β-Arrestins

    Arrestins have now been implicated in the actions of virtually every G protein-coupled receptor (GPCR) for which they have been examined. Originally discovered for their role in the turnoff of visual perceptio...

    Marc G. Caron, Lawrence S. Barak in Beta-Arrestins (2019)

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    Protocol

    Green Fluorescent Protein-Tagged β-Arrestin Translocation as a Measure of G Protein-Coupled Receptor Activation

    The G protein-coupled receptor (GPCR) superfamily is the largest family of integral membrane proteins. GPCRs respond to a wide variety of sensory and chemical stimuli and contribute directly to the regulation ...

    Stephen S. G. Ferguson, Marc G. Caron in G Protein Signaling (2004)

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    Protocol

    Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice

    One of the most valuable methods for understanding the function of a particular protein is the generation of animals that have had the gene encoding for the protein of interest disrupted, commonly known as a “...

    Gary W. Miller, Yan-Min Wang, Raul R. Gainetdinov, Marc G. Caron in Parkinson's Disease (2001)