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    Single-Cell RNA-Seq Technologies and Computational Analysis Tools: Application in Cancer Research

    The recent maturation of single-cell RNA sequencing (scRNA-seq) provides unique opportunities for researchers to uncover new and potentially unexpected biological discoveries and to understand the complexity o...

    Qianqian Song, Liang Liu in Cancer Biomarkers (2022)

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    Airway Inflammation Biomarker for Precise Management of Neutrophil-Predominant COPD

    Chronic obstructive pulmonary disease (COPD) course can be divided into stable stage and acute exacerbation. Deepen the understanding to the function and role of airway inflammatory cells in stable COPD is imp...

    Xue Liang, Ting Liu, Zhiming Zhang, Ziyu Yu in Precision Medicine (2020)

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    Assays to Assess Arenaviral Glycoprotein Function

    Arenaviruses, such as Lassa virus (LASV) and Pichindé virus (PICV), are enveloped viruses with a bi-segmented ambisense RNA genome. The large (L) genomic segment encodes the Z matrix protein and the L RNA-depe...

    Junjie Shao, **aoying Liu, Yuying Liang, Hinh Ly in Hemorrhagic Fever Viruses (2018)

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    Manufacturing and Delivering Genome-Editing Proteins

    Genome-editing technologies have revolutionized the biomedical sciences by providing researchers with the ability to quickly and efficiently modify genes. While programmable nucleases can be introduced into ce...

    Jia Liu, Ya-jun Liang, Pei-ling Ren, Thomas Gaj in Zinc Finger Proteins (2018)

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    Renal Delivery of Anti-microRNA Oligonucleotides in Rats

    MicroRNAs are endogenous small, non-protein-coding RNA molecules that play an important role in the regulation of a wide variety of cellular functions and disease processes. A novel role for microRNAs in the d...

    Kristie S. Usa, Yong Liu, Terry Kurth, Alison J. Kriegel, David L. Mattson in Hypertension (2017)

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    Tangled Trees: The Challenge of Inferring Species Trees from Coalescent and Noncoalescent Genes

    Phylogenies based on different genes can produce conflicting phylogenies; methods that resolve such ambiguities are becoming more popular, and offer a number of advantages for phylogenetic analysis. We review ...

    Christian N. K. Anderson, Liang Liu, Dennis Pearl in Evolutionary Genomics (2012)