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Plasma Biomarkers of Alzheimer’s Disease and Neurodegeneration According to Sociodemographic Characteristics and Chronic Health Conditions
Ultrasensitive assays have been developed which enable biomarkers of Alzheimer’s disease pathology and neurodegeneration to be measured in blood....
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Development and validation of a risk prediction model for motoric cognitive risk syndrome in older adults
ObjectiveThe objective of this study was to develop a risk prediction model for motoric cognitive risk syndrome (MCR) in older adults.
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Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study
Telomeres undergo a progressive shortening process as individuals age, and it has been proposed that severely shortened and dysfunctional telomeres...
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Benefits of a family-based care transition program for older adults after hip fracture surgery
BackgroundHip fracture (HF) in older adults is strongly associated with a greater decline in their activities of daily living (ADLs) and...
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Voices Unheard: Navigating the Disempowerment of Older Adults in Family Dynamics in Kashmir (India)
This paper attempts to investigate the dwindling status of older adults within family settings in Kashmir, specifically focusing on their...
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The influence of sex-specific factors on biological transformations and health outcomes in aging processes
The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The...
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Explaining Socioeconomic Inequality in Psychological Well-being among Older People: A Comparison between Vietnam and Myanmar
Limited understanding exists regarding the social determinants of psychological well-being inequalities, particularly in develo** countries with...
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Exploring the complexity of EEG patterns in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily associated with motor dysfunctions. By the time of definitive...
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Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation
The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
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Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
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Relationship between quantitative physical activity and deterioration of locomotive function: a cross-sectional study using baseline data from a cohort
BackgroundIn aged society, health policies aimed at extending healthy life expectancy are critical. Maintaining physical activity is essential to...
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Childhood intra- and extra-familial maltreatment and later-life trajectories of depressive symptoms: evidence from China
BackgroundBoth late-life depression and childhood maltreatment have become major global public health issues, given their prevalence and...
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Differences of anticholinergic drug burden between older hospitalized patients with and without delirium: a systematic review and meta-analysis based on prospective cohort studies
ObjectivesThis review aims to comprehensively summarize the differences in anticholinergic drug burden (ADB) scores between older hospitalized...
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What determines informal care need among community-dwelling older adults in China? Results from a longitudinal study
BackgroundWith an intensified aging population and an associated upsurge of informal care need in China, there is an ongoing discussion around what...
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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1)...
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Association between antidepressant use and delirium in older adults: an analysis of the World Health Organization’s global pharmacovigilance database
BackgroundPsychoactive drugs frequently cause delirium adverse events in older adults. However, few data on the relationship between antidepressants...
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Universal Prevention of Dementia in Italy: A Document Analysis of the 21 Italian Regional Prevention Plans
BackgroundUp to 40% of dementia cases are theoretically avoidable and population-level interventions (i.e., universal prevention) are a key component...
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No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults
ObjectiveThis study aimed to investigate the relationship between childhood adversity and cognitive impairment in older adults.
Methods ...