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Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy
IntroductionNatural killer (NK) cell-based therapies are a promising new method for treating indolent cancer, however engineering new therapies is...
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Magnetoactive, Kirigami-Inspired Hammocks to Probe Lung Epithelial Cell Function
IntroductionMechanical forces provide critical biological signals to cells. Within the distal lung, tensile forces act across the basement membrane...
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Probing the Effects of Chirality on Self-Assembling Peptides: Hydrogel Formation, Degradation, Antigen Release, and Adjuvancy
IntroductionMultidomain peptides (MDPs) are amino acid sequences that self-assemble to form supramolecular hydrogels under physiological conditions...
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Primary Human Cell-Derived Extracellular Matrix from Decellularized Fibroblast Microtissues with Tissue-Dependent Composition and Microstructure
PurposeHuman extracellular matrix (ECM) exhibits complex protein composition and architecture depending on tissue and disease state, which remains...
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Cellular Traction Force Holds the Potential as a Drug Testing Readout for In Vitro Cancer Metastasis
IntroductionMetastasis is responsible for 90% of cancer-related deaths worldwide. However, the potential inhibitory effects of metastasis by various...
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A Label-Free Colorimetric AuNP-Aptasensor for the Rapid Detection of Vibrio cholerae O139
PurposeWaterborne pathogens pose a significant threat to public health, emphasizing the continuous necessity for advancing robust detection...
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P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress
PurposeP300 is a lysine acetyltransferase that plays a significant role in regulating transcription and the nuclear acetylome. While P300 has been...
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Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy
IntroductionThe diffusion of cell components such as proteins is crucial to the function of all living cells. The abundance of macromolecules in...
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Field Guide to Traction Force Microscopy
IntroductionTraction force microscopy (TFM) is a widely used technique to measure cell contractility on compliant substrates that mimic the stiffness...
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Pioglitazone Antagonized the Effects of Advanced Glycation End Products on Achilles Tendon Healing and Improved the Recovery of Tendon Biomechanical Properties
PurposeAdvanced glycation end products (AGEs) often accumulate in the Achilles tendon during the course of diabetes. This study aims to determine the...
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Glioblastoma Cells Use an Integrin- and CD44-Mediated Motor-Clutch Mode of Migration in Brain Tissue
PurposeGlioblastoma (GBM) is an aggressive malignant brain tumor with 2 year survival rates of 6.7% (Stupp et al. in J Clin Oncol Off J Am Soc Clin...
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Three-Dimensional Tumor Models to Study Cancer Stemness-Mediated Drug Resistance
Solid tumors often contain genetically different populations of cancer cells, stromal cells, various structural and soluble proteins, and other...
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Pathological Features of Colorectal Adenocarcinoma Patients Related to MLH1
BackgroundMLH1, one of the MMR proteins, is linked to DNA replication, its role being to repair the incorrect DNA sequences and to replace them with...
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A Model for Chemomechanical Coupling of Kinesin-3 Motor
IntroductionKinesin-3 motor, which is in the monomeric and inactive form in solution, after cargo-induced dimerization can step on microtubules...
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Influence of Hematocrit Level and Integrin αIIbβIII Function on vWF-Mediated Platelet Adhesion and Shear-Induced Platelet Aggregation in a Sudden Expansion
PurposeShear-mediated thrombosis is a clinically relevant phenomenon that underlies excessive arterial thrombosis and device-induced thrombosis. Red...
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Neurogenic Cell Behavior in 3D Culture Enhanced Within a Highly Compliant Synthetic Hydrogel Platform Formed via Competitive Crosslinking
PurposeScaffold materials that better support neurogenesis are still needed to improve cell therapy outcomes for neural tissue damage. We have used a...
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Incorporation of ChatGPT and Other Large Language Models into a Graduate Level Computational Bioengineering Course
The remarkable capabilities of generative artificial intelligence and large language models (LLMs) such as ChatGPT have delighted users around the...
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Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors
IntroductionBreast tumors often display an astonishing degree of spatial and temporal heterogeneity, which are associated with cancer progression,...
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Trisomy 21 Alters Cell Proliferation and Migration of iPSC-Derived Cardiomyocytes on Type VI Collagen
PurposeIndividuals with Down syndrome (DS) are 2000 times more likely to develop a congenital heart defect (CHD) than the typical population Freeman...
