1,084 Result(s)
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Chapter and Conference Paper
Resveratrol: From Basic Studies to Bedside
Plants produce a remarkable amount of low molecular mass natural products endowed with a large array of pivotal biological activities. Among these molecules, resveratrol (3,5,4’-trihydroxystilbene) has been id...
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Chapter and Conference Paper
Sulforaphane as a Promising Molecule for Fighting Cancer
Cancer is a complex disease characterized by multiple genetic and molecular alterations involving transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis. To grow, inva...
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Chapter and Conference Paper
Epigenetics and Epidemiology: Models of Study and Examples
Epidemiological studies have successfully identified several environmental causes of disease, but often these studies are limited by methodological problems (e.g. lack of sensitivity and specificity in exposur...
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Chapter and Conference Paper
Breast Cancer and the Importance of Early Life Nutrition
Epigenetic processes play a central role in regulating the tissue-specific expression of genes. Alterations in these processes can lead to profound changes in phenotype and have been implicated in the pathogen...
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Chapter and Conference Paper
Life Style Prevention of Cancer Recurrence: The Yin and the Yang
There is increasing evidence that lifestyle after the diagnosis of cancer may affect prognosis. Several studies have shown that a Western dietary pattern, obesity, weight gain, a sedentary lifestyle, metabolic...
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Chapter and Conference Paper
The Role of Metabolic Carcinogenesis in Cancer Causation and Prevention: Evidence from the European Prospective Investigation into Cancer and Nutrition
The theory that nutrition might be involved in the causation and prevention of cancer arose over 100 years ago from laboratory studies of the effect of diet on tumour growth. During the mid-20th century, the m...
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Chapter and Conference Paper
A Holistic Approach to Study the Effects of Natural Antioxidants on Inflammation and Liver Cancer
The limited effectiveness of chemotherapy and the high recurrence rate of cancers highlight the urgent need to identify new molecular targets and to develop new treatments. Numerous epidemiological studies hav...
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Chapter and Conference Paper
Gut Microbes, Diet, and Cancer
An expanding body of evidence supports a role for gut microbes in the etiology of cancer. Previously, the focus was on identifying individual bacterial species that directly initiate or promote gastrointestina...
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Chapter and Conference Paper
Fruits and Vegetables: Updating the Epidemiologic Evidence for the WCRF/AICR Lifestyle Recommendations for Cancer Prevention
The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) current dietary recommendations for cancer prevention include “eating at least five portions/servings of a variety of non-starc...
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Chapter and Conference Paper
Nutriomes and Personalised Nutrition for DNA Damage Prevention, Telomere Integrity Maintenance and Cancer Growth Control
DNA damage at the base sequence and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome ...
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Chapter and Conference Paper
Mediterranean Dietary Pattern and Chronic Diseases
The study of the relationship between the Mediterranean way of eating and the occurrence of diseases typical of the economically developed countries has been considered the starting point of nutritional epidem...
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Chapter and Conference Paper
Concluding Remarks
An attempt at summarizing, however incompletely, the variety of topics and research perspectives as presented at the third conference of “Advances in Nutrition and Cancer” in Naples, May 2012 and herein report...
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Chapter and Conference Paper
Alcoholic Beverages and Carbonated Soft Drinks: Consumption and Gastrointestinal Cancer Risks
Alcoholic beverages (ABs) and carbonated soft drinks (CSDs) are widely consumed worldwide. Given the high consumption of these beverages, the scientific community has increased its focus on their health impact...
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Chapter and Conference Paper
Selenium and Cancer: A Story that Should not be Forgotten-Insights from Genomics
Selenium (Se) is an essential micronutrient that is incorporated into selenoproteins. Although epidemiological studies suggest that low Se intake is associated with increased risk of various cancers, the resul...
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Chapter and Conference Paper
Quercetin: A Pleiotropic Kinase Inhibitor Against Cancer
Increased consumption of fruits and vegetables can represent an easy strategy to significantly reduce the incidence of cancer. From this observation, derived mostly from epidemiological data, the new field of ...
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Chapter and Conference Paper
Functions, Aberrations, and Advances for Chromatin Modulation in Cancer
Cancer initiation and progression is causally connected to genome and epigenome deregulations. Epigenetic deregulations (such as DNA methylation, histone modifications, and miRNA-based modulation) have been in...
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Chapter and Conference Paper
Dietary Epigenetics in Cancer and Aging
Although epigenetic aberrations frequently occur in aging and cancer and form a core component of these conditions, perhaps the most useful aspect of epigenetic processes is that they are readily reversible. U...
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Chapter and Conference Paper
Olive Oil and Other Dietary Lipids in Breast Cancer
Breast cancer is the most frequent malignant neoplasia among women worldwide. In addition to genetic and endocrine factors, the environment, and specifically nutritional factors, plays a key role in its aetiol...
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Chapter and Conference Paper
New Perspective for an Old Antidiabetic Drug: Metformin as Anticancer Agent
Metformin, an inexpensive, well-tolerated oral agent that is commonly used in the first-line treatment for type 2 diabetes, has become the focus of intense research as a potential anticancer agent. This resear...
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Chapter and Conference Paper
Obesity, Energy Balance, and Cancer: A Mechanistic Perspective
Nearly 36 % of adults and 20 % of children in the USA are obese, defined as a body mass index (BMI) ≥30 kg/m2. Obesity, which is accompanied by metabolic dysregulation often manifesting in the metabolic syndrome...
