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Medicine & Public Health
Metabolic Diseases
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Conference Paper
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Chapter and Conference Paper
ts-Oncogene-Transformed Erythroleukemic Cells: A Novel Test System for Purifying and Characterizing Avian Erythroid Growth Factors
An emerging, important characteristic of many leukemic cell types is their altered dependence on and/or response to hematopoietic growth factors [6, 17]. In mammals, many of these growth-regulatory proteins ha...
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Chapter and Conference Paper
Viral Transduction of Host Genes in Naturally Occurring Feline T-Cell Leukaemias: Transduction of myc and a T-Cell Antigen Receptor β-Chain Gene
Feline leukaemia virus has been a particularly useful tool in cancer research since many of the naturally occurring tumours associated with this virus group have yielded recombinant retroviruses containing hos...
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Chapter and Conference Paper
Neutralization and Receptor Recognition of Human T-Lymphotropic Retroviruses
Like other enveloped viruses, the outer membrane antigens of retroviruses present target antigens for neutralizing antibodies, and also play a key role in interacting with cell-surface receptors for initial st...
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Chapter and Conference Paper
Intra-arterial Cis-platinum in Osteosarcoma
Conventional radiography continues to be the most important imaging modality in the initial diagnosis and assessment of skeletal neoplasms. However, this technique is usually inadequate to determine the local ...
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Chapter and Conference Paper
Implications of Sweetness in Upbringing and Education
According to The Shorter Oxford English Dictionary, education means “the systematic instruction, schooling or training given to the young (and, by extension, to adults) in preparation for the work of life”. From ...
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Chapter and Conference Paper
Molecular Properties and Biological Activity of Human Macrophage Growth Factor, CSF-1
CSF-1 belongs to a family of colony-stimulating factors (CSF) that regulate the production of the blood cells (Metcalf 1986). CSF-1 is a specific growth and differentiation factor for bone marrow progenitor ce...
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Chapter and Conference Paper
Proliferative Effects of a Recombinant Human Granulocyte Colony-Stimulating Factor (rG-CSF) on Highly Enriched Hematopoietic Progenitor Cells
Human multipotential and committed hematopoietic progenitor cells require the presence of specific glycoproteins, termed “colony-stimulating factors” (CSFs) for survival, clonal proliferation, and differentiat...
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Chapter and Conference Paper
Replication and Pathogenesis of the Human T-Cell Leukemia/Lymphotropic Retroviruses
Human retroviruses represent an emerging class of complex pathogens involved in a wide variety of maladies, including leukemias and lymphomas, diseases of the central nervous system, and immune function impair...
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Chapter and Conference Paper
Ablative Therapy Supported by Autologous Bone Marrow Transplantation with In Vitro Treatment of Marrow in Patients with B-Cell Malignancy
Patients with non-Hodgkin’s lymphoma who relapse almost invariably die as a consequence of the disease regardless of histological subtype [1–4]. Ablative therapy supported by autologous bone marrow transplanta...
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Chapter and Conference Paper
Sweetness in Product Development
Sweetness has long been a key to the improvement of food acceptability, but until the development of the sugar industry some six centuries ago, sources were limited to fruits, honey, maple and carob syrup. Bef...
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Chapter and Conference Paper
Cellular Specificity and Molecular Characteristics of the Binding of Colony-Stimulating Factors to Normal and Leukemic Cells
The colony-stimulating factors (CSFs) form a family of hemopoietic growth factors controlling the survival, proliferation and differentiation of hemopoietic progenitor cells as well as the functional activitie...
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Chapter and Conference Paper
Cloning of Human Thymic Subcapsular Cortex Epithelial Cells by SV40 ori− Transfection
Critical steps in the early differentiation of T lymphocytes occur within the thymus. Bone-marrow derived cells migrating into this organ undergo extensive proliferation, clonal rearrangement of antigen recept...
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Chapter and Conference Paper
LAV/HTLV-III: Fine-structure Analysis, Localization of Structural Proteins, and Detection of Envelope Antigens by Patient Sera
LAV/HTLV-III was investigated by thinsection and immunoelectron microscopy. Formation of the virion takes place at the cell membrane. The inner components are assembled concomitant with budding, as is characte...
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Chapter and Conference Paper
Improvement of HIV Serodiagnosis
Experience is described with four different assays to detect antibodies against the HIV. ELISA tests using HTLV-III from two different cell lines or the bacterially synthesized envelope peptide ENV(80)-DHFR we...
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Chapter and Conference Paper
Monoclonal-Antibody-Purged Autologous Bone Marrow Transplantation for Relapsed Non-T-Cell Acute Lymphoblastic Leukemia in Childhood
Acute lymphoblastic leukemia (ALL) in childhood is a curable disease for the majority of patients [1]. Most children who relapse, however, have a poor prognosis. Although second complete remission can usually ...
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Chapter and Conference Paper
Interaction of Promoters and Oncogenes During Transfection
DNA transfection in recipient NIH3T3 mice cells is most widely used for identification of transforming genes in human tumor cells [1]. We showed earlier that c-Ha-ras proto-on-cogene from a human malignant glioma...
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Chapter and Conference Paper
Neurophysiological Aspects of Sweetness
In the natural environment, sweetness can nearly always be equated with energy. Consequently its detection is associated with a powerful hedonic appeal which declines only as energy needs are met. In this chap...
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Chapter and Conference Paper
Modification of Oncogenicity of Tumour Cells by DNA-Mediated Gene Transfer
Major histocompatibility complex (MHC) class I antigens (termed H-2K, D and L in mice) are widely distributed on nearly all cell types and play an indispensable role in immunoregulation: lysis of neoplastic ce...
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Chapter and Conference Paper
Restricted Neutralization of Divergent HTLV-III/LAV Isolates by Antibodies to the Major Envelope Glycoprotein
By analogy to other retroviruses, the major envelope glycoprotein — gp120 — of HTLV-III/LAV is a probable target for neutralizing antibody. This antigen has been purified from H9 cells chronically infected wit...
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Chapter and Conference Paper
Growth of the HTLV-III Strain of Human Immunodeficiency Virus in Different Cell Types
The major immunological abnormality in the acquired immunodeficiency syndrome (AIDS) appears to be a quantitative defect in the T4 antigen-positive helper/inducer T-cell subset. AIDS is etiologically linked to...
