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  1. No Access

    Chapter and Conference Paper

    cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson’s disease

    cDNA microarray membranes comprising 1,200 different gene fragments have been employed to identify gene expression profile in MPTPinduced nigro striatal dopamine neurodegeneration and its protection with R-apo...

    S. Mandel, E. Grünblatt, M. Youdim in Advances in Research on Neurodegeneration (2000)

  2. No Access

    Chapter and Conference Paper

    Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine

    There have been many attempts to discover neuroprotective drugs for the treatment of Parkinson’s disease (PD). Many ofthese compounds either do not cross the blood brain barrier or are not very effective in th...

    Prof. M. B. H. Youdim, M. Gassen, A. Gross… in Advances in Research on Neurodegeneration (2000)

  3. No Access

    Chapter and Conference Paper

    Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity

    Apomorphine is a potent radical scavenger and iron chelator. In vitro apomorphine acts as a potent iron chelator and radical scavenger with IC50 of 0.3 μM for iron (2.5 μM) induced lipid peroxidation in rat brain...

    E. Grünblatt, S. Mandel, M. Gassen… in Advances in Research on Neurodegeneration (1999)