77 Result(s)
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Chapter and Conference Paper
ABCAE: Artificial Bee Colony Algorithm with Adaptive Exploitation for Epistatic Interaction Detection
The detection of epistatic interactions among multiple single-nucleotide polymorphisms (SNPs) in complex diseases has posed a significant challenge in genome-wide association studies (GWAS). However, most exis...
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Chapter and Conference Paper
PCPI: Prediction of circRNA and Protein Interaction Using Machine Learning Method
Circular RNA (circRNA) is an RNA molecule different from linear RNA with covalently closed loop structure. CircRNAs can act as sponging miRNAs and can interact with RNA binding protein. Previous studies have r...
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Chapter and Conference Paper
scGASI: A Graph Autoencoder-Based Single-Cell Integration Clustering Method
Single-cell RNA sequencing (scRNA-seq) technology offers the opportunity to study biological issues at the cellular level. The identification of single-cell types by unsupervised clustering is a basic goal of ...
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Chapter and Conference Paper
A Network-Based Voting Method for Identification and Prioritization of Personalized Cancer Driver Genes
Identifying cancer driver genes is an important task in cancer research. Numerous methods that identify these driver genes have been proposed, most of which identify driver genes in entire patient cohorts. How...
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Chapter and Conference Paper
Fusing Label Relations for Chinese EMR Named Entity Recognition with Machine Reading Comprehension
Chinese electronic medical records named entity recognition (NER) is a core task in medical knowledge mining, which is usually viewed as a sequence labeling problem. Recent works introduce the machine reading ...
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Chapter and Conference Paper
TDCOSR: A Multimodality Fusion Framework for Association Analysis Between Genes and ROIs of Alzheimer’s Disease
The complementary multimodality data fusion analysis provides a new perspective for revealing associations between genes and brain regions of interests (ROIs) of Alzheimer’s disease (AD). In this paper, we pro...
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Chapter and Conference Paper
Sensitivity Analysis of Adhesion in Computational Model of Elastic Doublet
This work introduces a computational model of elastic double cluster. We describe a method to create a partially flattened spherical cell and a mirroring process that creates a symmetrical double cluster with ...
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Chapter and Conference Paper
EEG-Based Emotion Recognition Fusing Spacial-Frequency Domain Features and Data-Driven Spectrogram-Like Features
Research on emotion recognition based on EEG (electroencephalogram) signals has gradually become a hot spot in the field of artificial intelligence applications. The recognition methods mainly include designin...
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Chapter and Conference Paper
Improving Protein-protein Interaction Prediction by Incorporating 3D Genome Information
Numerous computational methods have been proposed to predict protein-protein interactions, none of which however, considers the original DNA loci of the interacting proteins in the perspective of 3D genome. He...
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Chapter and Conference Paper
Exploiting Multi-granular Features for the Enhanced Predictive Modeling of COPD Based on Chinese EMRs
Building a predictive model to understand a patient’s status and the future progression of disease is an important precondition for facilitating preventive care to reduce the burden of chronic obstructive pulm...
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Chapter and Conference Paper
SuccSPred: Succinylation Sites Prediction Using Fused Feature Representation and Ranking Method
Protein succinylation is a novel type of post-translational modification in recent decade ...
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Chapter and Conference Paper
The Classification System and Biomarkers for Autism Spectrum Disorder: A Machine Learning Approach
Autism spectrum disorder (ASD) is a kind of neurodevelopmental disorder. ASD patients are usually difficult in social communication and daily life, and there are no drugs to cure ASD. A large number of clinica...
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Chapter and Conference Paper
Batch Weighted Nuclear-Norm Minimization for Medical Image Sequence Segmentation
Recently, convolutional neural networks have shown their superior performance for biomedical image sequence segmentation. Most of the current state-of-the-art segmentation methods are designed for segmentation...
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Chapter and Conference Paper
Taurine Prevented Hypoxia Induced Chicken Cardiomyocyte Apoptosis Through the Inhibition of Mitochondrial Pathway Activated by Calpain-1
Objective To determine whether taurine has protective effects on chicken myocardial apoptosis induced by hypoxic condition through inhibiting calpain-1 derived mitochondrial apoptotic pathway. Methods Chicken pri...
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Chapter and Conference Paper
Preventive or Curative Administration of Taurine Regulates Lipid Metabolism in the Liver of Rats with Alcoholic Liver Disease
Excessive consumption causes alcoholic liver disease (ALD), which injures hepatocytes and induces imbalance of lipid metabolism. Taurine is known to protect the liver from various liver injuries, and relieve l...
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Chapter and Conference Paper
Taurine Inhibited Uric Acid Uptake in HK-2 Renal Tubular Epithelial Cells
It has been confirmed by our laboratory that taurine could decrease uric acid levels in hyperuricemic rats and regulate the expressions of some urate transporters. The present study aims to investigate the eff...
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Chapter and Conference Paper
Taurine Improves Lipid Metabolism and Skeletal Muscle Sensitivity to Insulin in Rats Fed with High Sugar and High Fat Diet
Metabolic syndrome is a lifestyle-related disease caused by high nutrient condition and lack of exercise. The insulin resistance due to obesity has attracted attention as an underlying mechanism of metabolic s...
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Chapter and Conference Paper
Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells
Taurine displays anti-tumor activity in some kinds of human cancers. However, the underlying mechanisms are poorly understood. Epstein-Barr virus-related nasopharyngeal carcinoma (NPC) is a distinctive type of...
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Chapter and Conference Paper
Taurine Promotes In-vitro Follicle Development, Oocyte Maturation, Fertilization and Cleavage of rats
It is well known that a large quantity of taurine is present in mammalian ovaries. Taurine reportedly promotes the secretion of female reproductive hormones by stimulating hypothalamus-pituitary-gonadal axis f...
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Chapter and Conference Paper
Taurine Prevents the Electrical Remodeling in Ach-CaCl2 Induced Atrial Fibrillation in Rats
Objective: To study the preventive actions and mechanism of taurine on the electrical remodeling in atrial fibrillation (AF) rats. Methods: Male Wistar rats were injected with the mixture of acetylcholine (Ach) ...
