308 Result(s)
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Chapter and Conference Paper
Gastric Varices and Ectopic Varices
Acute bleeding from gastric and ectopic varices is a major complication of portal hypertension. Currently, treatment options for the management of GV include beta-blockers, endoscopic band ligation, endoscopic...
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Chapter and Conference Paper
Contemporary Opportunities in Nonsurgical Management of Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
The majority of head and neck squamous cell carcinoma (HNSCC) is now classified into two major types: HPV-mediated [HPV(+)] and HPV-negative [HPV(−)]. Within this paradigm, the 8th edition TNM staging system e...
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Chapter and Conference Paper
Genotypes and Phenotypes of Chinese Pediatric Patients with Idiopathic and Heritable Pulmonary Arterial Hypertension: Experiences from a Single Center
The aim of this study was to determine the clinical outcomes of gene mutations in Chinese pediatric patients with idiopathic and heritable pulmonary arterial hypertension. We screened gene mutations in 62 pedi...
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Chapter and Conference Paper
A Pilot Study of Gender Differences on Anthropometric Measurements in Singapore Population
This pilot study aims to collect 37 body dimensions within 12 standing and 25 sitting posture from 100 subjects and to investigate the gender difference of the subjects, aged from 17 to 60 years old. The mean ...
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Chapter and Conference Paper
Effect of Motion Type and Inclination on Muscle Activity and Edema
The purpose of the study was to assess the lower limb muscle activity and the leg volume changes associated with different motion types and inclination. Participants were asked to run and walk at two different...
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Chapter and Conference Paper
The Significance of Abnormal Muscle Response Monitoring During Microvascular Decompression for Hemifacial Spasm
Despite the wide adoption of the abnormal muscle response (AMR) to electrical stimulation of the facial nerve during microvascular decompression (MVD) surgery, the value of AMR in the prognosis of the postoper...
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Chapter and Conference Paper
Use of High-Resolution Ultrasonography in Anterior Subcutaneous Transposition of the Ulnar Nerve for Cubital Tunnel Syndrome
Cubital tunnel syndrome (CTS) is the most common form of ulnar nerve entrapment. In this study, ultrasonography (US) was used not only for diagnosis but also for operation. US findings could be used to establi...
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Chapter and Conference Paper
Combination of Magnetic Resonance Imaging and Electrophysiological Studies in Lumbar Disc Herniation
Objective We aimed to study the clinical value of magnetic resonance imaging (MRI) and electrophysiological studies in the diagnosis of lumbar disc herniation and in the evaluation of the therapeutic effect of d...
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Chapter and Conference Paper
Apolipoprotein E Isoforms and AMD
The cholesterol transporting protein apolipoprotein E (ApoE) occurs in three allelic variants in humans unlike in other species. The resulting protein isoforms E2, E3 and E4 exhibit differences in lipid bindin...
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Chapter and Conference Paper
Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration
An appropriate animal model is essential to screening drugs or designing a treatment strategy for geographic atrophy. Since oxidative stress contributes to the pathological changes of the retinal pigment epith...
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Chapter and Conference Paper
Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins
More than 100 different mutations in the RPE65 gene are associated with inherited retinal degeneration. Although some missense mutations have been shown to abolish isomerase activity of RPE65, the molecular bases...
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Chapter and Conference Paper
Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-Derived Retinal Pigment Epithelium Cells
Interest in generating human induced pluripotent stem (iPS) cells for stem cell modeling of diseases has overtaken that of patient-specific human embryonic stem cells due to the ethical, technical, and politic...
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Chapter and Conference Paper
Application of Next-Generation Sequencing to Identify Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa (adRP)
The goal of our research is to identify genes and mutations causing autosomal dominant retinitis pigmentosa (adRP). For this purpose we established a cohort of more than 250 independently ascertained families ...
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Chapter and Conference Paper
Knock-Down DHDDS Expression Induces Photoreceptor Degeneration in Zebrafish
A mutation in the dehydrodolichol diphosphate synthase (DHDDS) was recently identified as the cause of a subtype of recessive retinitis pigmentosa (RP). Molecular modeling indicates that this mutation could re...
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Chapter and Conference Paper
In Vivo Function of the ER-Golgi Transport Protein LMAN1 in Photoreceptor Homeostasis
LMAN1 is a type I transmembrane protein that selectively transports its cargo proteins from ER to ER-Golgi intermediate compartment (ERGIC) and Golgi. Lman1 is a direct target of the transcription factor NRL in m...
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Chapter and Conference Paper
Gene Therapy in the Rd6 Mouse Model of Retinal Degeneration
The rd6 mouse is a natural model of an RPE-based (retinal pigment epithelium) autosomal recessive retinitis pigmentosa (RP) caused by mutations in the Mfrp (membrane-type frizzled related protein) gene. Previousl...
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Chapter and Conference Paper
Determinants for More Efficient Defibrillation Waveforms
Defibrillation is accomplished by delivering a high energy shock, which creates a large electric field throughout heart and simultaneously depolarizes a sufficient mass of excitable cells thereby restoring spo...
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Chapter and Conference Paper
Cytokine Marker Measurement in Human Neuroblastoma Cells with Supersensitive and Multiplex Assay: MUSTag Technology
Background: Recently, various sets of protein biomarkers have been discovered in important diseases such as cancers, brain stroke and heart attack. However, clinical validation is difficult and ti...
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Chapter and Conference Paper
Vasospasm After Subarachnoid Hemorrhage: A 3D Rotational Angiography Study
Background and Purpose: The purpose of this study was to investigate the clinical value of 3D rotational angiography (3DRA) for evaluation of cerebral vasospasm in patients with aneurysmal suba...
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Chapter and Conference Paper
Enhanced Angiogenesis and Astrocyte Activation by Ecdysterone Treatment in a Focal Cerebral Ischemia Rat Model1
Background and Purpose: We reported previously that ecdysterone (EDS) improves neurologic function after experimental stroke. However, the underlying mechanism remained unclear. The present stu...
