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    Chapter and Conference Paper

    Lipid Gene Trasfer, a Story of Simplicity and Complexity

    It is 10 years since the first description of the use of a positively charged lipid to deliver nucleic acids to mammalian cells (Feigner et al., 1987). In essence the methodology of liposome-mediated transfer of ...

    Natasha J. Caplen in Gene Therapy (1998)

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    Chapter and Conference Paper

    Gene Therapy for Cancer

    Cancer is a complex acquired disease that affects millions of individuals each year. Underlying the pathogenesis of cancer are a variety of molecular genetic abnormalities which can be inherited or environment...

    Susan A. Zullo, Natasha J. Caplen, R. Michael Blaese in Gene Therapy (1998)

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    Chapter and Conference Paper

    Lipid Gene Transfer and Clinical Gene Therapy

    There are several features of liposome-mediated DNA transfer that make it a viable delivery system for clinical gene therapy. 1) In contrast to viral delivery systems, contamination with exogenous protein or o...

    Natasha J. Caplen in Gene Therapy (1998)