![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Chapter and Conference Paper
Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat
There exists no pharmacological treatment for fulminating brain edema. Since evidence indicates that brain aquaporin-4 (AQP4) water channels are modulated by vasopressin V1a receptors, we examined the edema-re...
-
Chapter and Conference Paper
Bolus tracer delivery measured by MRI confirms edema without blood-brain barrier permeability in diffuse traumatic brain injury
Previous studies have shown that edema formation after diffuse traumatic brain injury (TBI) with secondary insult is cytotoxic and not vasogenic. This assumption is based on observations of reduced apparent di...
-
Chapter and Conference Paper
Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema
The protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), is known to interact with aquaporin-4 (AQP4), a waterselective transporting protein abundant in astrocytes and ependymal cells, that has b...
-
Chapter and Conference Paper
Traumatic brain edema in diffuse and focal injury: cellular or vasogenic?
The objective of this study was to confirm the nature of the edema, cellular or vasogenic, in traumatic brain injury in head-injured patients using magnetic resonance imaging techniques. Diffusion-weighted ima...
-
Chapter and Conference Paper
Brain tissue water content in patients with idiopathic normal pressure hydrocephalus
Relatively little is known regarding the water content of brain tissue in idiopathic normal-pressure hydrocephalus (NPH) patients. The objective of our study was to determine absolute water content non-invasiv...
-
Chapter and Conference Paper
Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat
Dimethyl sulfoxide (DMSO) is widely used as a solvent for other drugs, i.e., for the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) and the V1a receptor-antagonist SR49059, to reduce brain ed...
-
Chapter and Conference Paper
Comparison of NAA Measures by MRS and HPLC
This work investigates the accuracy of an in vivo estimation of absolute N-acetyl aspartate (NAA) concentrations by magnetic resonance spectroscopy (MRS) using cerebral water as an internal reference standard....
-
Chapter and Conference Paper
CSF and ECF Glutamate Concentrations in Head Injured Patients
Excitatory Amino Acids (EAAs) release has been considered to be neurotoxic in traumatic brain injury patients. Microdialysis samples of extracellular space (ECS) and high glutamate concentrations in cerebrospi...
-
Chapter and Conference Paper
Biphasic Pathophysiological Response of Vasogenic and Cellular Edema in Traumatic Brain Swelling
The objective of this study was to quantify the temporal water content changes and document the type of edema (cellular versus vasogenic) that is occurring during both the acute and the late stages of edema de...
-
Chapter and Conference Paper
The Fine Structural Study of Brain Response to Intracerebral Infusion of Serum in the Cat
The mechanism of vasogenic edema resolution is unclear and is a subject of investigation at various laboratories, including our own. Our previous studies using the infusion model of brain edema indicated disti...
-
Chapter and Conference Paper
Development of Brain Edema Following Fluid Percussion Injury
The progressive increase in brain volume following severe mechanical injury ultimately leads to intracranial ischemia and hypertension. The severity of the problem is in part reflected in the statistic that 50...