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Chapter and Conference Paper
Evidence for an Initiation Mechanism of 17β-Estradiol Carcinogenesis
17β-estradiol (E2), the endogenous female hormone, is carcinogenic causing uterine and breast cancers. The mechanism is unknown. We found that E2 could be activated by the epoxide-forming oxidant dimethyldioxiran...
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Chapter and Conference Paper
Carcinomas of the Oropharynx Treated with Hyperfractionated Radiation Therapy on Radiation Therapy Oncology Group Protocol 8313
Squamous cell carcinomas of the oropharynx are among the sites within the upper aerodigestive tract most consistently treated with radiation therapy. The ability to observe directly the response to radiation t...
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Chapter and Conference Paper
Ovarian Hormones Enhance the Carcinogenic Activity of 2,3,7,8-TCDD in Rats
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a hepatocarcinogen in female rats but not male rats. Our studies, employing a two-stage model for hepatocarcinogenesis, reveal a significant difference between intact...
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Chapter and Conference Paper
Minimal Cervical Cancer: Definition and Histology
The concept of a prognostically favorable, early cervical cancer was first proposed by Mestwerdt (1947) as “microcarcinoma,” which he defined as a lesion that invades less than 5 mm into the cervical stroma me...