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SARS-CoV-2 und andere neu auftretende Virusinfektionen
Neu auftretende Infektionserkrankungen stellen eine besondere Bedrohung für die öffentliche Gesundheit dar. Oft handelt es sich bei den...
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Molekulares Tumorboard
Die Technologie der Next-Generation-Sequenzierung hatte tiefgreifende Auswirkungen auf das Verständnis der Tumorgenetik und damit der Tumorbiologie...
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Fatal Hemorrhage Complicating Intracranial Stenting After Failed Thrombectomy for Intracranial Atherosclerotic Stenosis in a Patient with Moderate Stroke: Risk Factors for Hemorrhagic Transformation, Red Flags, and Lessons Learned
Most large vessel occlusions (LVOs) are secondary to emboli of cardiac or cervical artery origin. Current stent retrieval and aspiration thrombectomy...
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Preoperative Diagnostics
First the possible prenatal diagnostics are explained. Then necessary preoperative diagnostic steps are laid down. This applies to the general...
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Surgical Treatment
General considerations concerning the timepoint and type of surgery are given in this chapter. Craniotomies are due in the first year of life. Facial...
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Strip Craniectomy Procedures Combined with Helmet Therapy
General considerations according to literature are laid down. Minimally invasive surgery with endoscopic support is demonstrated for sagittal suture...
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Traumatic Brain Injury in Pregnancy
Traumatic brain injury may cause significant morbidity and mortality in the pregnant trauma patient. Although there are minor differences, the...
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The Central Role of Specialized Neurocritical Care Teams: Standards of Neurologic Critical Care Units
Intensive care units evolved over the past century to become an integral part of the hospital system. Intensivists provide care for the most...
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Clinical and Bioethical Perspective on Brain Death, Organ Donation, and Family Communication
The concept of brain death emerged about 60 years ago, when the development of ventilators and other intensive care unit technologies allowed...
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Multiple Trauma Management: Treatment of Abdominal Injury in Combination with Trauma Brain Injury
Patients with combined head and abdominal trauma present unique challenges to the trauma team, namely in how to prioritize injuries, determine...
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Sedation, Pain, and Delirium in Patients with Traumatic Brain Injury
The objectives of sedation/analgesia in patients with severe traumatic brain injury (TBI) are focused on preventing alterations in brain perfusion...
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Temperature Control and the Role of Therapeutic Hypothermia in Traumatic Brain Injury
Currently there are limited therapeutic interventions that have been reported to improve functional outcomes in patients with traumatic brain injury...
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Out-of-Hospital Management of Traumatic Brain Injury
The out-of-hospital management of patients with suspected traumatic brain injury should focus on initial management of airway, breathing, and...
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Infection Management in the Neurocritical Care Setting
Central nervous system infections are frequently seen in patients with penetrating head trauma or neurosurgical procedures or instrumentation....
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Seizure: Prophylaxis and Treatment in Acute Brain Injury
Prophylaxis for post-traumatic seizures is a current practice to avoid the morbidity and potential secondary brain injury associated with...
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Understanding Midazolam: The Key to Its Safe Clinical Use
Understanding midazolam involves understanding its chemistry, pharmacokinetics, and pharmacodynamics. These are the topics where holding a...
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Routes of Midazolam Administration
Midazolam being a versatile drug can be administered through various routes including intravenous, oral, intranasal, intramuscular, rectal, and oral...
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Pre-operative Assessment: The Key to Safe Sedation Outcomes
Midazolam is a very safe drug by all counts. A sound knowledge of the child’s systemic background will further enhance its safety profile by aiding...
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Genetics of Small Vessel Disease
Cerebral small vessel disease (CSVD) is highly prevalent in the general population and is overall a leading cause of disability. CSVD manifestations...
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Fluid Management in Trauma
Fluid therapy is one of the major interventions in primary survey to sustain life during acute trauma. Over the years, it has evolved with new...