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In Vitro and In Silico ADME Prediction
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and...
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Blood Flow Distribution and Membrane Transporters as Determinant Factors of Tissue Drug Concentration
The free drug hypothesis states that the non-ionized free drug concentrations will have the same value in all the aqueous spaces of the body, once...
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Introduction: Biopharmaceutics and Pharmacokinetics
Biopharmaceutics and Pharmacokinetics are pharmaceutical disciplines that are useful for improving the outcome of drug therapies, assisting drug...
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Drug-Drug and Food-Drug Interactions of Pharmacokinetic Nature
The most relevant pharmacokinetic mechanisms of drug-drug (DD) and food-drug (FD) interactions are summarized from a perspective that will allow the...
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Advanced Techniques for Quality Assessment of Nanocarriers
Nanoparticle characterization is crucial for develo** and optimizing nanocarriers, as it is necessary to have a comprehensive understanding of...
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Regulatory Requirements and Applications of Physiologically Based Pharmacokinetic Models
Physiologically based pharmacokinetic (PBPK) models have become a key tool to reduce the uncertainty and assure the best benefit-risk decisions in a...
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Vaccine Safety Surveillance
Vaccine safety surveillance is an essential component of public health initiatives to assure the safety and effectiveness of vaccination programs....
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Reporting of ADRs Across the Globe: India, USA, EU, and Non-EU
This chapter conducts a comparative analysis of adverse drug reaction (ADR) reporting practices in four prominent global regions: India, the United...
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Impact of Aging, Lifestyle, and Phytochemicals on the Commencement of Neurological Disorders
Neurodegenerative diseases (NDs) are examples of neurological disorders. Common NDs include Alzheimer’s disease (AD), Parkinson’s disease (PD),...
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Bioactive Compounds of Algae: Potential Neuroprotective Agents in Neurodegenerative Disorders
Neurodegenerative diseases are diverse in nature and are characterized by the continuous loss of neurons, glial cells, and neural networks in the...
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The Controversy Surrounding Drugs Against Neurodegenerative Disorders: Benefit or Harm?
The global healthcare system and public health are burdened by Alzheimer’s, Parkinson’s, and Huntington’s diseases. Due to their increasing...
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Phytochemicals as Protective Agents for Brain Aging
Aging is the major danger agent for many age-related disorders, including neurological diseases. Knowing the biological mechanisms of aging is...
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Neurotrophins and Phytochemicals: Potential Partners to Combat Neurodegenerative Diseases
Neurotrophins and phytochemicals have emerged as promising areas of research in the field of neuroscience and human health. Neurotrophins are a group...
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Microfluidics Integrated Biosensors: Design, Fabrication, and Testing
Microfluidic systems have been quite thoroughly discussed throughout this chapter book, though it is through biosensors that such systems reveal...
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Applications of Microfluidics in Cancer Diagnosis and Treatment
Cancer is one of the leading causes of mortality globally, with a possibility to prevent many of these incidents via enhancing lifestyle habits and...
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Microfluidic Production of Inorganic Nanoparticles
Inorganic nanoparticles (NPs) have considerable potential for biomedical applications, such as drug delivery, cancer imaging, and cell tracking....
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Microfluidic Technologies for Precise Drug Delivery
There is a current demand for new and more sophisticated drug delivery systems (DDSs) to efficiently deliver therapeutics to the desired tissues,...
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Microfluidic Point-of-Care Devices
The provision of healthcare has been revolutionized by the development of microfluidic point-of-care (POC) devices as revolutionary tools in medical...
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Nanocarriers: Delivery Routes
Nanocarriers have crucial applications in medicine, mainly in drug delivery. The choice of administration route assumes significance during the drug...
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The Relationship Between Pharmacogenomics and Pharmacokinetics and Its Impact on Drug Choice and Dosing Regimens in Pediatrics
The concept of precision or personalized medicine in pediatrics is still in its infancy, and it is difficult to conduct clinical studies in...