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Current Topics Regarding the Function of the Medial Temporal Lobe Memory System
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were...
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Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature mortality among people with epilepsy (PWE). The overall incidence rate of...
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In Silico Models to Validate Novel Blood-Based Biomarkers
Biological validation of preliminary findings is a key prerequisite in biomarker discovery. In recent years, the development of advanced large-scale...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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Tissue-Segment Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor’s Natural Environment
The pharmacological and biochemical properties of G protein-coupled receptors have been recently revealed to be more complex than originally...
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Allosteric Modulation of Ligand Binding to Muscarinic Receptors
Allosteric ligands bind to a site on the receptor different from the primary (orthosteric) site. They modulate the binding and function of muscarinic...
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Detection of Non-neuronal Acetylcholine
The biological role of acetylcholine and the cholinergic system has been revisited within the last decades. Acetylcholine and the pivotal components...
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Systems for a Long-Term Record of Animal Activity, Temperature, and Heart Rate Affected by Muscarinic Receptors
The muscarinic receptors have many effects on physiological parameters and behavior. There are several ways to obtain the data from the organism...
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Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies Using Muscarinic Receptor Knockout Mouse
To investigate the functional roles of M2 and M3 muscarinic receptors in mouse atria, wild-type mice, muscarinic M2 or M3 single receptor knockout...
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Evaluation of Acetylcholine Synthesis and Release in Striatal Cholinergic Interneurons
Acetylcholine (ACh), an essential neurotransmitter in the central nervous system (CNS), plays important roles in brain functions, such as memory and...
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Post-traumatic Epilepsy and Neuropsychiatric Comorbidities
Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that arises from traumatic brain injury (TBI). It presents a complex relationship with...
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Additional Models and Derivations
Much of what we have described in the preceding chapters provides the basic tools necessary to build physiological state-space estimators. In this...
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Texture Estimation for Abnormal Tissue Segmentation in Brain MRI
This chapter discusses multifractal texture estimation and characterization of brain lesions (necrosis, edema, enhanced tumor, nonenhanced tumor,...
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Fractal-Based Analysis of Histological Features of Brain Tumors
The structural complexity of brain tumor tissue represents a major challenge for effective histopathological diagnosis. Tumor vasculature is known to...
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Fractal Analysis of the Cerebrovascular System Pathophysiology
The cerebrovascular system is characterized by parameters such as arterial blood pressure (ABP), cerebral perfusion pressure (CPP), and cerebral...
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Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases
The fractal dimension is a morphometric measure that has been used to investigate the changes of brain shape complexity in aging and...
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Fractal Analysis in Neurodegenerative Diseases
Neurodegenerative diseases are defined by progressive nervous system dysfunction and death of neurons. The abnormal conformation and assembly of...
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Computational Fractal-Based Analysis of MR Susceptibility-Weighted Imaging (SWI) in Neuro-Oncology and Neurotraumatology
Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique able to depict the magnetic susceptibility produced by...
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Point of Care Testing (POCT) in Psychopathology Using Fractal Analysis and Hilbert Huang Transform of Electroencephalogram (EEG)
Research has shown that relying only on self-reports for diagnosing psychiatric disorders does not yield accurate results at all times. The advances...
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Fractal-Based Morphometrics of Glioblastoma
Morphometrics have been able to distinguish important features of glioblastoma from magnetic resonance imaging (MRI). Using morphometrics computed on...