63 Result(s)
within
Chapter
Yi** **
English
Metabolic Diseases
Neurosciences
-
Chapter
Drosophila as a Model Organism
Drosophila melanogaster has been widely used in classical and modern genetics for more than 100 years. The history of the Drosophila model in the study of various aspects of life sciences will be summarized in t...
-
Chapter
Alzheimer’s Disease Model System Using Drosophila
Alzheimer’s disease (AD) is the most epidemic neuronal dysfunctions among elderly people. It is accompanied by neuronal disorders along with learning and memory defects, as well as massive neurodegeneration ph...
-
Chapter
Repeat Expansion Disease Models
Repeat expansion disorders are a group of inherited neuromuscular diseases, which are caused by expansion mutations of repeat sequences in the disease-causing genes. Repeat expansion disorders include a class ...
-
Chapter
Drosophila Charcot-Marie-Tooth Disease Models
Charcot-Marie-Tooth disease (CMT) was initially described in 1886. It is characterized by defects in the peripheral nervous system, including sensory and motor neurons. Although more than 80 CMT-causing genes ...
-
Chapter
Muscular Dystrophy Model
Muscular dystrophy (MD) is a group of muscle weakness disease involving in inherited genetic conditions. MD is caused by mutations or alteration in the genes responsible for the structure and functioning of mu...
-
Chapter
From Drosophila Blood Cells to Human Leukemia
The hematopoietic system plays a critical role in establishing the proper response against invading pathogens or in removing cancerous cells. Furthermore, deregulations of the hematopoietic differentiation pro...
-
Chapter
Drosophila Models to Investigate Insulin Action and Mechanisms Underlying Human Diabetes Mellitus
Diabetes is a group of metabolic diseases in which the patient shows elevated levels of blood sugar. In healthy condition, there is the regulatory system that maintains constant glucose levels in blood. It is ...
-
Chapter
Humanized Flies and Resources for Cross-Species Study
The completion of whole-genome sequences has greatly broadened our understanding of genes and genomes. The availability of model organism databases facilitates the sharing of information. However, it is still ...
-
Chapter
Adult Intestine Aging Model
The Drosophila adult has an intestine composed of a series of differentiated cells and tissue stem cells, all of which are similar to the mammalian intestinal cells. The aged adult intestine shows apparent charac...
-
Chapter
Parkinson’s Disease Model
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD...
-
Chapter
Amyotrophic Lateral Sclerosis Model
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects upper and lower motor neurons in the brain and the spinal cord. Due to the progressive neurodegeneration, ALS leads to para...
-
Chapter
Drosophila as a Model to Gain Insight into the Role of lncRNAs in Neurological Disorders
It is now clear that the majority of transcription in humans results in the production of long non-protein-coding RNAs (lncRNAs) with a variable length spanning from 200 bp up to several kilobases. To date, we...
-
Chapter
Drosophila As a Cancer Model
Over the last few decades, Drosophila cancer models have made great contributions to our understanding toward fundamental cancer processes. Particularly, the development of genetic mosaic technique in Drosophila ...
-
Chapter
Diseases Associated with Mutation of Replication and Repair Proteins
Alterations in proteins that function in DNA replication and repair have been implicated in the development of human diseases including cancer, premature ageing, skeletal disorders, mental retardation, microce...
-
Chapter
Metabolomics: State-of-the-Art Technologies and Applications on Drosophila melanogaster
Metabolomics is one of the latest “omics” technology concerned with the high-throughput identification and quantification of metabolites, the final products of cellular processes. The revealed data provide an ...
-
Chapter
Designs for Flies + of Mice and Men: Design Approaches to Drosophila melanogaster
Designs for Flies is an award-winning design-led interdisciplinary project between KYOTO Design Lab (D-Lab), the Department of Applied Biology at the Kyoto Institute of Technology (KIT) and Charcot-Marie-Tooth (...
-
Chapter and Conference Paper
Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities
We report an expression and purification procedure to produce homogeneous, active human DP8 and DPIV. The most interesting discovery was that DP8 specifically has both prolyl dipeptidyl aminopeptidase and PEP ...
-
Chapter and Conference Paper
Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR
-
Chapter and Conference Paper
Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y
-
Chapter and Conference Paper
Peptide Substrates of Dipeptidyl Peptidases
