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  1. No Access

    Chapter and Conference Paper

    The Structural Basis of Contraction and Regulation in Skeletal Muscle

    The purpose of this review will be to present sufficient of the background information about the structure of muscle, as well as some details of recent work, so that a non-specialist can form a reasonably-cohe...

    H. E. Huxley in Molecular Basis of Motility (1976)

  2. No Access

    Chapter and Conference Paper

    The Binding and Cleavage of ATP in the Myosin and Actomyosin ATPase Mechanisms

    One of H.H. Weber’s great contributions to muscle biochemistry and physiology was his understanding of the essential role of ATP in muscle contraction, so clearly expressed in his 1954 review (Weber and Port-z...

    J. F. Eccleston, M. A. Geeves, D. R. Trentham, C. R. Bagshaw… in Molecular Basis of Motility (1976)

  3. No Access

    Chapter and Conference Paper

    Energy Transformation in Muscle

    I wish to begin by paying tribute to Professor H.H. Weber both as a scientist and as a warm-hearted human being.

    D. R. Wilkie in Molecular Basis of Motility (1976)

  4. No Access

    Chapter and Conference Paper

    Phosphorylation and the Regulation of the Function of Myosin and the Troponin Complex

    There is now good evidence that three well-characterized enzymes pre-cent in muscle can catalyse the phosphorylation by ATP of proteins of the myofibril (Table 1).

    S. V. Perry, H. A. Cole, N. Frearson, A. J. G. Moir… in Molecular Basis of Motility (1976)

  5. No Access

    Chapter and Conference Paper

    The Role of the Interaction of Ca2+ with Troponin in the Regulation of Muscle Contraction

    In introducing this paper, that is dedicated to the memory of Professor H.H. Weber and deals with some aspects of the interaction of calcium and one of the regulatory proteins of muscle, it is fitting to recal...

    J. D. Potter, B. Nagy, J. H. Collins, J. C. Seidel… in Molecular Basis of Motility (1976)

  6. No Access

    Chapter and Conference Paper

    Concerted Regulation of Glycogen Metabolism and Muscle Contraction

    Whenever a muscle contracts, glycogen immediately breaks down to provide the energy necessary to maintain contraction. We propose to discuss here how these two physiological processes can be simultaneously tri...

    E. H. Fischer, J.-U. Becker, H. E. Blum, B. Byers… in Molecular Basis of Motility (1976)

  7. No Access

    Chapter and Conference Paper

    Microfilaments in Blood Platelets

    Blood platelets or thrombocytes are formed by fragmentation of the cytoplasm of the megakaryocyte and therefore contain no nucleus. Nevertheless they are equipped with a wide variety of subcellular structures:...

    E. F. Lüscher in Molecular Basis of Motility (1976)

  8. No Access

    Chapter and Conference Paper

    Phallotoxins and Microfilaments

    Phalloidin (Formula 1a) is one of the toxic components of the toadstool Amanita phalloides (Wieland, 1968); it is accompanied in the mushroom by several toxic relatives of which only phallacidin (Formula 1b) is s...

    Th. Wieland in Molecular Basis of Motility (1976)

  9. No Access

    Chapter and Conference Paper

    Hans Hermann Weber In Memoriam

    Es ist das erste Mal, daß in Deutschland ein Symposium über die kontraktilen Strukturen von Muskeln und Zellen stattfindet. Alle, die auf diesem Grenzgebiet zwischen Physiologie, Biochemie und Biophysik in Deu...

    W. Hasselbach in Molecular Basis of Motility (1976)

  10. No Access

    Chapter and Conference Paper

    An Investigation of the Cross-bridge Cycle Using ATP Analogues and Low-angle X-ray Diffraction from Glycerinated Fibres of Insect Flight Muscle

    The interdigitating filament arrays of muscle contain as their major components the proteins actin and myosin. Globular actin molecules aggregate to form the “thin” filaments. Myosin molecules consist of fully...

    K. C. Holmes, R. S. Goody, H. G. Mannherz… in Molecular Basis of Motility (1976)

  11. No Access

    Chapter and Conference Paper

    The Kinetics of Cross-bridge Turnover

    I would like to describe some methods that have been used to study the kinetics of cross-bridge turnover in muscle cells, and to tell you about some of the results that have been obtained. The structural basis...

    R. J. Podolsky in Molecular Basis of Motility (1976)

  12. No Access

    Chapter and Conference Paper

    Release and Uptake of Calcium by the Sarcoplasmic Reticulum

    Today it seems well established that calcium ions are the mediators of excitation contraction coupling. The sequence of the reactions by which muscle activity is twitched on starts with the depolarization of t...

    W. Hasselbach in Molecular Basis of Motility (1976)

  13. No Access

    Chapter and Conference Paper

    Myosin-linked Calcium Regulation

    It is generally accepted that all muscles contract by a relative sliding of the actin and myosin filaments past each other and that regulation of this contractile activity is controlled by the concentration of...

    J. Kendrick-Jones in Molecular Basis of Motility (1976)

  14. No Access

    Chapter and Conference Paper

    Microtubules: Inhibition of Spontaneous in vitro Assembly by Non-neural Cell Extracts

    Microtubules are a class of subcellular organelles found in all eukary-otic organisms. In general these structures are long cylinders with a diameter of approximately 24 nm and an apparently hollow core some 1...

    J. Bryan, B. W. Nagle in Molecular Basis of Motility (1976)

  15. No Access

    Chapter and Conference Paper

    Studies on the Interaction of the Nerve Growth Factor with Tubulin and Actin

    Fibrillar proteins can be defined in operational terms as “modular elements” endowed with the property of forming structures which may serve different functions in different cells or also in the same cell duri...

    P. Calissano, A. Levi, S. Alemà, J. S. Chen… in Molecular Basis of Motility (1976)

  16. No Access

    Chapter and Conference Paper

    Final Comments

    The Mosbach colloquia were held to fulfil two purposes: firstly, to review a field of main interest for non-specialists; secondly, to stimulate the exchange of new ideas and new concepts among specialists from...

    Professor Dr. L. Heilmeyer in Molecular Basis of Motility (1976)

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    Chapter and Conference Paper

    Welcome

    Ich möchte Sie herzlich begrüßen und am Symposium über molekulare Grundlagen der Motilität willkommen heißen. Sie erlauben mir jetzt sicher, vor allem im Hinblick auf unsere vielen Gäste und der Internationali...

    J. C. Rüegg in Molecular Basis of Motility (1976)

  18. No Access

    Chapter

    [Norleucine3,6]-Substituted Cholecystokinin Octapeptide Analogues

    Cholecystokinin octapeptide (CCK-8, Fig. 1) is a neurogastric peptide hormone and neurotransmitter that possesses multiple biological activities (Table I). Cholecystokinin octapeptide is one of several molecul...

    Tomi K. Sawyer, Douglas J. Staples… in Neural and Endocrine Peptides and Receptors (1986)

  19. No Access

    Chapter

    Modulation of Carboxypeptidase Processing Enzyme Activity

    Regulation of peptide hormone biosynthesis can occur at several cellular levels: transcription of the peptide hormone gene, RNA processing, translation of the mature mRNA, and posttranslational processing of t...

    Vivian Y. H. Hook, Lee E. Eiden… in Neural and Endocrine Peptides and Receptors (1986)

  20. No Access

    Chapter

    β-Lipotropin

    Pituitary extracts have been known for nearly 50 years to contain fat-mobilizing or lipolytic activity. Now that pituitary hormones have been isolated and their primary structures are known, it is possible to ...

    Choh Hao Li in Neural and Endocrine Peptides and Receptors (1986)

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