61 Result(s)
within
Life Sciences
Biochemistry, general
Food Science
Neurosciences
Pharmacology/Toxicology
Yi** **
Chapter
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Chapter and Conference Paper
Glutathione Metabolism as Affected by Selenium Deficiency
Glutathione (GSH) is a tripeptide-y-glutamylcysteinylglycine. GSH synthesized in the liver is transported across the sinusoid into the blood. The liver is the only tissue that releases GSH to the systemic circ...
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Chapter and Conference Paper
Biochemical Studies on Selenium and Keshan Disease — The Oxidant Stress and Defence Capacity in Blood of Selenium-Deficient Children
In China, the daily selenium intake of humans varied widely, from 7 μg to 38 mg (Yang 1987), thus the individual selenium status is quite different. The population in Keshan disease areas where an endemic card...
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Chapter and Conference Paper
Is Selenium Metabolism Necessary for Its Anticarcinogenic Activity?
At the Third International Selenium Symposium held in Bei**g in 1984, I presented a talk entitled, “Susceptibility of Mammary Carcinogenesis in Response to Dietary Selenium Levels” (Ip 1987). Since the curren...
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Chapter and Conference Paper
Regulation of Expression of Glutathione Peroxidase by Selenium
Selenium was shown in 1957 to be an essential dietary nutrient for the rat (Schwarz and Foltz 1957). In the same year, Mills (1957) reported the discovery of an enzyme, glutathione peroxidase (GSH-Px, GSH: H2O2 o...
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Chapter and Conference Paper
Selenium Intake Induces Growth Retardation Through Reversible Growth Hormone and Irreversible Somatomedin C Suppression
Growth retardation is an outstanding symptom in animals exposed to toxic doses of selenium and is one of the main symptoms in stocks with alkali disease. Even Moxon (1937) demonstrated a convincing correlation...
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Chapter and Conference Paper
Selenium-Containing Proteins in Plasma of Higher Primates
Only one major selenium-containing peak was found when animal plasma was subjected to gel filtration (Sephadex G-150) (Beilstein and Whanger 1983). The selenium peak eluted slightly ahead of the glutathione pe...
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Chapter and Conference Paper
Effect of Selenium on Adriamycin-Induced Cardiotoxicity in Mice
One of the most effective antitumor drugs is adriamycin (ADR) which produces a dose-related cardiomyopathy that can limit its clinical use. The ADR-induced, subacute cardiomyopathy seen in the mouse is morphol...
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Chapter and Conference Paper
The Use of Highly Enriched 77Se in Metabolic Studies of Ebselen in Man — An NMR Investigation
There is a lot of prejudice against selenium. The element per se is considered to be toxic, irrespective of its molecular surroundings. This rather uncritical view obviously does not hold true for organoseleno...
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Chapter and Conference Paper
Dependence of Mouse Liver Phospholipid Hydroperoxide Glutathione Peroxidase on Dietary Selenium
In addition to the selenoenzyme glutathione peroxidase (GSH-Px), another enzyme catalyzing the reduction of hydroperoxides by oxidation of GSH has been recently discovered (Ursini et al. 1982) and named “perox...
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Chapter and Conference Paper
Myocardial and Pancreatic Damage in Selenium Vitamin E Deficient Mice
Selenium-vitamin E (Se-E) deficiency in animals produces a wide spectrum of target organ lesions including involvement of the heart, skeletal muscles, smooth muscle, liver, pancreas, stomach, adipose tissue, s...
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Chapter and Conference Paper
Ebselen (PZ-51) Inhibits the Formation of Ischemic Brain Edema
Recent evidence has suggested the involvement of lipoxygenase metabolites (Asano et al. 1985; Dempsey et al. 1986) and/or active oxygen such as superoxide anion (Chan et al. 1985) in the development of ischemi...
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Chapter and Conference Paper
Selenium-Independent Glutathione Peroxidase in Malaria Parasites
Inherited and/or acquired alterations of red blood cell metabolism, like glucose-6-phosphate dehydrogenase- or vitamin E deficiency, which influence peroxide metabolism, inhibit the regular intracellular devel...
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Chapter and Conference Paper
Ebselen, a Seleno-Organic Compound, Inhibits Leukocyte Aggregation and Reduces the Plasma Leukotriene B4 Level in Humans and Rats
Recent evidence suggests that intravascular activation of leukocytes may be implicated in the pathogenesis of inflammation, postischemic injury and atherothrombotic diseases (Harlan 1985). Thus, the prevention...
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Chapter and Conference Paper
Protection of Experimental Cobalt Cardiomyopathy in the Rat by Selenium Pretreatment
Clinical evidence has implicated cobalt (Co) in the etiology of a primary myocardial disease occurring among certain heavy beer drinkers when Co was added to the beer (McDermott et al. 1966; Bonenfant et al. 1...
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Chapter and Conference Paper
Selenium Status and Cardiovascular Disease: Dutch Epidemiologic Data
Several mechanisms have been suggested which link selenium to myocardial ischemia (Salonen 1987). The antioxidant hypothesis is most popular and quite well established by experimental studies. A decreased glut...
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Chapter and Conference Paper
Progress in Establishing Human Nutritional Requirements and Dietary Recommendations for Selenium
In 1980, the Committee on Dietary Allowances of the U.S. National Research Council established the first human dietary standard for selenium (National Research Council 1980). This standard, called an “Estimate...
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Chapter and Conference Paper
Studies of Human Maximal and Minimal Safe Intake and Requirement of Selenium
Although the geographical relationship between human cancer incidence and local environmental Se status has been repeatedly confirmed since 1969 (Shamberger and Frost 1969), the levels of Se used in animal stu...
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Chapter and Conference Paper
Reactions of the Thioredoxin System with Selenium
Thioredoxin is a small (Mr = 12000) ubiquitous redox protein with the conserved active site structure: -Trp-Cys-Gly-Pro-Cys- (Holmgren 1985). The oxidized form (trx-S2) contains a disulfide bridge which is reduce...
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Chapter and Conference Paper
Blood Selenium Levels of Norwegians Compared to Their Se Intakes
Norwegian soils are known to be poor in selenium. Normally this would imply low blood-Se levels in the population. Several investigations (Blekastad et al. 1984; Meltzer et al. 1985; Ringstad et al. 1987) have...
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Chapter and Conference Paper
Effects of Selenium Supplementation on Platelet Function as Assessed by Platelet Aggregation and Glutathione Peroxidase Activity
Increased platelet aggregation and an altered arachidonic acid metabolism was reported in selenium-deficient animals (Schoene et al. 1986; Bryant et al. 1983). The selenium-dependent enzyme glutathione peroxid...
