18 Result(s)
within
Biomedicine
Cancer Research
Oncology
Wen-**g **ng
Chapter
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Chapter
Cancer Stem Cells in Patient Survival and Therapies in Cancer
Cancer stem cells (CSCs) are a subpopulation of cancer cells and responsible for stemness properties of cancer cell. It is regarded as one of the major causes of cancer formation, recurrence, and metastasis. R...
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Tight Junctions in Human Urinary Bladder Cancer
The majority of patients, who die from bladder cancer, ultimately do so from metastasis. A breakdown in the cell-cell bond seems likely to occur both, between cancer cells for tumour migration and between urot...
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Programming of MDSC: New Opportunities for Targeted Therapy
Myeloid-derived suppressor cells have recently been widely recognized as major players in tumor-mediated immunosuppression. MDSCs act to suppress antitumor immunity through increased production of Arginase, Re...
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Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing)
Tight Junctions (TJ) control the paracellular diffusion of ions and certain molecules and it has become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ st...
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Engineering Stem Cell Niche: Regulation of Cellular Morphology and Function
Stem cells with the capacity to differentiate into a variety of tissue lineages are promising cell sources for tissue repair and regeneration. Their properties and behaviours are highly regulated by the “niche...
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Glioma: Role of Integrin in Pathogenesis and Therapy
Despite the current standard treatments including surgical resection, radiation therapy and chemotherapy for maliganat gliomas, the survival of these patients remains dismal. More effective therapies are urgen...
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Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells
As described in the previous chapter, the loss of E-cadherin is the key event in epithelial–mesenchymal transition. While downregulation of E-cadherin could occur via aberrant Akt signaling, direct somatic mut...
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Linking Human RecQ Helicases to DNA Damage Response and Aging
Maintenance of genome integrity is crucial for the survival of an organism. Increasing evidence suggests that defective DNA damage response promotes genome instability and accelerates age-related degeneration....
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Treatment of High-Grade Gliomas in Adults
Surgery, radiation therapy, and chemotherapy with temozolomide are the mainstays of treatment for patients with high-grade gliomas. The addition of temozolomide leads to a significant improvement in 2-year sur...
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Polyunsaturated Fatty Acids and Prostate Cancer Metastasis
Polyunsaturated fatty acids have been demonstrated to have anticancer activities, on a number of tumor types including prostate cancer. There is evidence that these fatty acids may also influence the metastati...
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The role of the HGF regulatory factors in breast cancer
Hepatocyte growth factor (HGF) plays a pivotal role in the invasion and motility of breast cancer cells, and is also a key angiogenic and lymphangiogenic factor. The cytokine, which is primarily synthesised as...
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Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis
Metastasis is a life-threatening event in tumor bearing patients resulting in total organ failure and to subsequent death. Understanding the fundamental processes involved in how cancer cells detach from the p...
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Lymphangiogenesis and metastatic spread of breast cancer
Lymphangiogenesis, the growth and formation of new lymphatic vessels, has been extensively studied in recent years. With the identification of new lymphangiogenic factors and new lymphatic markers, the role of...
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New roles of glutathione peroxidase-1 in oxidative stress and diabetes
Glutathione peroxidase-1 (GPX1) was identified as an antioxidant enzyme in 1957 and as a selenoprotein in 1972. In the last ten years, ample data have been generated from several lines of GPX1 knockout mice, s...
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Growth Factor Receptors and Cell Adhesion Complexes in Cytoskeletal Assembly/Anchorage
Cell adhesions mediate major sites for the facilitation of cytoskeletal anchor protein assembly and organisation within cells, forming tightly regulated membrane domains. These membrane domain anchor proteins,...
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Polyunsaturated Fatty Acids and Their Role in Cancer Invasion and Metastasis
Highly unsaturated fatty acids (HUFAs) have been demonstrated to have anticancer functions in the past decade. Recently, these fatty acids have been shown to exert a regulatory action on tumour cell motility, ...
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Tight Junctions, a Critical Structure in the Control of Cancer Invasion and Metastasis
Tight junction is the apical most structure in epithelium as well as in the endothelium. Its main function is to control the paracellular diffusion of ions and certain molecules. Although the structure has bee...
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Metastatic Cascade, Molecular/Cellular Events and New Therapeutic Opportunities
Metastasis is the most life threatening event in patients with cancer. The process is composed of a number of sequencial events, of which tumour cells have to successfully complete. The understanding of the bi...
