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γ-Linked Dipeptide Analogues of 2-Desamino-2-Methyl-N10-Propargyl-5,8-Dideazafolate as Antitumour Agents
Quinazoline analogues of folic acid have been developed successfully as thymidylate synthase (TS) inhibitors which possess clinical activity. CB3717 (N10-propargyl-5,8-dideazafolic acid), the first of these agent...