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γ-Linked Dipeptide Analogues of 2-Desamino-2-Methyl-N¹⁰-Propargyl-5,8-Dideazafolate as Antitumour Agents

Quinazoline analogues of folic acid have been developed successfully as thymidylate synthase (TS) inhibitors which possess clinical activity. CB3717 (N¹⁰-propargyl-5,8-dideazafolic acid), the first of these agent...

A. L. Jackman, G. M. F. Bisset… in Chemistry and Biology of Pteridines and Fo… (1993)