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    1,2- Versus 1,4-Asymmetric Addition of Grignard Reagents to Carbonyl Compounds

    The first copper(I)-catalysed conjugate addition of Grignard reagents to α,β-unsaturated carbonyl compounds was reported in 1941. Impressive developments have been made since then, with catalytic asymmetric ad...

    Pablo Ortiz, Francesco Lanza… in Progress in Enantioselective Cu(I)-catalyz… (2016)