5 Result(s)
within
Chapter
Steven M Opal
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Chapter
A Brief History of Microbiology and Immunology
Vaccine history is inextricably linked with the histories of microbiology and immunology; evolution of the latter disciplines parallels the ongoing quest of humankind to understand the fundamental basis of lif...
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Chapter
Vaccines Against Bacterial Endotoxins
The use of vaccines that induce antibodies to either highly conserved epitopes in the LPS core or to serotype-specific antigens (O-polysaccharide or CPS) remains a viable strategy for the prevention and/or tre...
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Chapter
Immunopathogenesis of Gram-Negative Shock
It has become evident that Gram-negative bacterial pathogens have evolved an elaborate array of virulence factors that contribute to the immunopathogenesis of systemic infection and septic shock. Microorganism...
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Chapter
Interleukin-11: Potential Therapeutic Activity in Systemic Inflammatory States
Interleukin-11 IL-11) is a multifunctional, immunoregulatory cytokine with several unique attributes that has therapeutic potential in a number of systemic inflammatory states. Like many other pleiotropic cyto...
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Chapter
Endotoxin scavengers as a therapeutic strategy for sepsis
Bacterial endotoxin remains an important therapeutic target for the treatment of serious infections from Gram-negative bacterial pathogens. Despite recent failures in past clinical trials with novel anti-endot...
