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Chapter and Conference Paper
Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety
Our recent studies aimed to elucidate the molecular and biochemical mechanism of actions of the novel anti-Parkinson’s drug, rasagiline, an irreversible and selective monoamine oxidase (MAO)-B inhibitor and it...
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Chapter and Conference Paper
cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson’s disease
cDNA microarray membranes comprising 1,200 different gene fragments have been employed to identify gene expression profile in MPTPinduced nigro striatal dopamine neurodegeneration and its protection with R-apo...
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Chapter and Conference Paper
Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine
There have been many attempts to discover neuroprotective drugs for the treatment of Parkinson’s disease (PD). Many ofthese compounds either do not cross the blood brain barrier or are not very effective in th...
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Chapter and Conference Paper
Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity
Apomorphine is a potent radical scavenger and iron chelator. In vitro apomorphine acts as a potent iron chelator and radical scavenger with IC50 of 0.3 μM for iron (2.5 μM) induced lipid peroxidation in rat brain...