15 Result(s)
within
Chapter
Qi** Li
Immunology
Medical Microbiology
Virology
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Chapter
Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria
Mycobacteria, from saprophytic to pathogenic species, encounter diverse environments that demand metabolic versatility and rapid adaptation from these bacteria for their survival. The human pathogen Mycobacterium...
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Chapter
Mutational Profile of HPV-Positive HNSCC
This chapter summarizes the mutational profile of head and neck squamous cell cancer (HNSCC) associated with infection of the human papillomavirus (HPV). Focusing on next-generation sequencing studies, the dif...
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Humanized Mouse Versus Non-human Primate Models of HIV-1 Infection
Animal models are critical for biomedical research including human immunodeficiency virus type one (HIV-1). Asian non-human primate (NHP) macaques and humanized mice (hu-mice) are the two best available models...
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NK Cell Development in Human Immune System (HIS) Mice and Their Role in HIV Pathogenesis
Studies on mouse natural killer (NK) cells reveal their major role in host innate immunity against viral pathogens and tumor cells. In recent years, there has been a growing interest to develop therapeutics an...
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Thymic Education of Human T Cells and Regulatory T Cell Development in Humanized Mice
The thymus is an organ that generates and educates T cells, supplying T subsets that ensure adaptive immunity and self-tolerance. Intrathymic positive selection of T cells with further post-thymic maturation a...
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Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells
Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4+ T cells, the main target of HIV-1 replication. H...
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Chromatin Remodeling and Androgen Receptor-Mediated Transcription
It has become apparent that the expression of human genes in chromatin is regulated by post-translational structural changes in histones, which form the major protein component of nucleosomes in chromatin. The...
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Chapter
Images of Cleavage: Tumor Proteases in Action
The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrices during tumor invasion and metastasis. Furthermore, proteases from tumor-associated cells (e.g...
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Regulation of Mouse Hepatitis Virus RNA synthesis by Heterogeneous Nuclear Ribonucleoprotein Al
Mouse hepatitis virus (MHV) RNA synthesis, including replication of viral genome and transcription of subgenomic mRNAs, has been shown to be regulated by several viral RNA elements, including 5’-untranslated r...
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Differential Expression of Tumor Necrosis Factor in Primary Glial Cell Cultures Infected with Demyelinating and Non-Demyelinating MHVs
TNF-α is a monocyte/macrophage derived cytokine with multiple biological activities that are antitumorigenic, cytotoxic, and pro-inflammatory in nature. TNF-α mediates cellular response through two distinct ce...
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Demyelination Determinants in the S Gene of MHV
Demyelination is the hallmark pathologic process of several viral-induced, and inflammatory, immune-mediated diseases of the central nervous system (Allen and Bradkin 1993). Several experimental animal model s...
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The Effect of the T1087N S Gene Mutation on MHV-A59 Pathogenesis
Infection with mouse hepatitis virus (MHV) strain A59 produces acute hepatitis, encephalitis and chronic demyelination in mice (Lavi et al 1984). A closely related strain, MHV-2, produces acute meningitis and hep...
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Chapter
Programmed Cell Death in MHV-Induced Demyelination
Coronavirus mouse hepatitis virus (MHV) strain A59 causes severe acute hepatitis, focal meningoencephalitis, and chronic demyelinating disease of the spinal cord. It serves as an experimental model for multipl...
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Chapter and Conference Paper
Antigen Specific T Cell Nonresponsiveness in Man: Lepromatous Leprosy, a Model Disease
One of the most intriguing aspects of leprosy is the close correlation between its clinical and immunological spectrum. There are two polar forms of the disease, tuberculoid and lepromatous leprosy, with a num...
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Chapter and Conference Paper
Inflammation and Angiogenesis
Acute inflammation (i.e., caused by a superficial infection) is generally associated only with dilated vessels in the microcirculation of the skin. In chronic inflammation, dilated blood vessels are also accom...
