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  1. No Access

    Chapter

    Inflammatory Components of the Thyroid Cancer Microenvironment: An Avenue for Identification of Novel Biomarkers

    The incidence of thyroid cancer in the United States is on the rise with an appreciably high disease recurrence rate of 20–30%. Anaplastic thyroid cancer (ATC), although rare in occurrence, is an aggressive fo...

    Tara Jarboe, Neha Y. Tuli… in Tumor Microenvironment: Cellular, Metaboli… (2021)

  2. No Access

    Chapter

    Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity

    Thyroid cancer incidence is increasing at an alarming rate, almost tripling every decade. About 44,280 new cases of thyroid cancer (12,150 in men and 32,130 in women) are estimated to be diagnosed in 2021, wit...

    Sanjukta Chakraborty, Michelle Carnazza… in Tumor Microenvironment: Cellular, Metaboli… (2021)

  3. No Access

    Chapter

    Expression of Selected Aurora A Kinase Substrates in Solely Estrogen-induced Ectopic Uterine Stem Cell Tumors in the Syrian Hamster Kidney

    Sustained over-expression of Aurora A (AurA), centrosome amplification, chromosomal instability, and aneuploidy are salient features that occur in high frequency in human breast premalignant stages and in prim...

    Adrianne E. Hontz, Sara A. Li, Jeffrey L. Salisbury… in Hormonal Carcinogenesis V (2008)

  4. No Access

    Chapter

    Estrogen-Induced Breast Oncogenesis: Modulation by an Aurora Kinase Inhibitor

    Breast cancer (BC) alone accounts for about 32% of all cancers occurring in women in industrialized countries, and thus, is clearly an immense world wide public health concern. More than 90% of all human BC ca...

    Sara Antonia Li, Luke K. T. Lam, Nayaz Ahmed… in Hormonal Carcinogenesis V (2008)

  5. No Access

    Chapter

    Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment

    Sex hormone-binding globulin (SHBG), a plasma protein that binds androgens and estrogens, also participates in the initial steps of a membrane-based steroid signaling pathway in human prostate and breast. We h...

    Scott M. Kahn, Yu-Hua Li, Daniel J. Hryb, Atif M. Nakhla… in Hormonal Carcinogenesis V (2008)

  6. No Access

    Chapter

    Chromosomal Instability: A New Paradigm for Estrogen-induced Oncogenesis

    Jonathan J. Li, Jeffrey Salisbury, Sara Antonia Li in Hormonal Carcinogenesis IV (2005)

  7. No Access

    Chapter

    Characterization of Genetic Polymorphism of Glycine N-Methyltransferase Gene in Hepatocellular Carcinoma

    Previously, we reported that glycine N-methyltransferase (GNMT) expression levels were diminished in human liver cancer. Herein, the polymorphisms of GNMT in 5 hepatocellular carcinoma (HCC) and 2 hepatoblasto...

    Yu-Chuen Huang, Yi-** Shih, Chun-Chih Li, Li-Ying Liao… in Hormonal Carcinogenesis IV (2005)

  8. No Access

    Chapter

    Cytogenetic Analysis of Genomic Destabilization in Solely Estrogen-Induced Female ACI Rat Mammary Neoplasms

    A high frequency of aneuploid cells in carcinoma in-situ (CIS) and in small and large mammary tumors of female ACI rats are induced by estrogen (E) treatment alone. Employing G-banding karyotype analysis, consist...

    Dan Papa, Jonathan J. Li, Sara Antonia Li in Hormonal Carcinogenesis IV (2005)

  9. No Access

    Chapter

    Polymorphism of the Estrogen Receptor-β Gene in Breast Cancer

    Microsatellite polymorphism may influence gene expression or receptor signaling function. In cancer, microsatellite sequences, even when located in non-coding regions of a gene, are capable of modifying the su...

    Cristina Caraion, Nadine Vincent, Claude Lambert… in Hormonal Carcinogenesis IV (2005)

  10. No Access

    Chapter

    Pathologic, Clinical, and Epidemiologic Characteristics of Invasive Lobular Breast Carcinoma and a Review of Studies Evaluating its Association with Hormone Replacement Therapy

    Christopher I. Li in Hormonal Carcinogenesis IV (2005)