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Chapter
Mutational Profile of HPV-Positive HNSCC
This chapter summarizes the mutational profile of head and neck squamous cell cancer (HNSCC) associated with infection of the human papillomavirus (HPV). Focusing on next-generation sequencing studies, the dif...
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Chapter
Chromatin Remodeling and Androgen Receptor-Mediated Transcription
It has become apparent that the expression of human genes in chromatin is regulated by post-translational structural changes in histones, which form the major protein component of nucleosomes in chromatin. The...
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Chapter
Images of Cleavage: Tumor Proteases in Action
The roles of proteases in cancer are now known to be much broader than simply degradation of extracellular matrices during tumor invasion and metastasis. Furthermore, proteases from tumor-associated cells (e.g...