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472 Result(s)
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Chapter
Knock-Out and Knock-In Technique for Finding Integrative Components that Contribute to Effect of Chinese Medicines
Elucidating the effective constituents of Chinese medicine (CM) is a big challenge due to its complex constituents and diverse interactions. Knock-out/knock-in technique is a promising strategy to reveal the i...
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Chromatographic Separation with On-Line (Bio)Assay, a Rapid Technique for Screening Active Compounds from Chinese Medicines
Due to the complex compositions of Chinese medicine (CM), how to rapidly and efficiently discovery the biologically active components from them is a huge challenge. Traditionally, tedious extraction-isolation-...
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Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology in 1975 (Kohler, Milstein. Nature. 256(5517):495–497, 1975). ...
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Key Scientific Issues in Research for Quality Control of Chinese Medicines
Quality control is the key for modernization and internationalization of traditional Chinese medicines (TCMs). Besides techniques, key scientific issues in research on quality control of TCMs are crucial for w...
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HPLC and HPLC–MS for Qualitative and Quantitative Analysis of Chinese Medicines
Active compounds derived from Chinese medicines (CMs) have already illustrated immense therapeutic potential over an array of different diseases, and served as an inexhausted source for drug discovery and deve...
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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosis
Treatment of the common life-limiting genetic disease cystic fibrosis (CF) has been transformed by small molecule therapeutics that target the root cause of the disease, pathogenic variants in the ATP-binding ...
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Exotoxins of Staphylococcus aureus
Staphylococcus aureus produces a variety of exotoxins, which are important virulence factors for S. aureus-related diseases. Representatively, staphylococcal enterotoxins induce staphylococcal food-born poisoning...
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Advances in Vaccine Adjuvants: Nanomaterials and Small Molecules
Adjuvants have been extensively and essentially formulated in subunits and certain inactivated vaccines for enhancing and prolonging protective immunity against infections and diseases. According to the types ...
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Applications of Pressurized Liquid Extraction in Quality Control of Traditional Chinese Medicines
For many bioactive chemicals contained in traditional Chinese medicines, pressurized liquid extraction has become a preferred green extraction method. This review goes over the extraction principles and how to...
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Advance and Challenge of Component-Effect Relationship in the Discovery of Active Components from Chinese Medicines
Active ingredients discovery has always been a hot topic for the research of Chinese medicines (CMs). The component-effect relationship is one of the widely used strategies for finding herbal active ingredient...
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Application of Thin-Layer Chromatography in Quality Control of Chinese Medicines
Thin-layer chromatography is a conventional analytical method in quality control of traditional Chinese medicines. Many advantageous characteristics make it an important technology in quality research. However...
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Application of Gas Chromatography and Gas Chromatography–Mass Spectrometry in Quality Control of Chinese Medicines
Gas chromatography (GC) is a well-known and widely employed technique for separation and analysis of the gaseous and volatile components. Modern GC technique was firstly invented by James and Martin in 1952 an...
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Quality Control of Chinese Medicines Using UPLC–MS
Quality control of Chinese medicines (CMs) is a difficult work because of their intrinsic complexity. UPLC-MS is at the forefront of this crucial challenge due to its prominent performance in qualitative and q...
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Chemometrics in Quality Control of Traditional Chinese Medicines
The modernization and globalization of traditional Chinese medicines (TCMs) require the implementation of a robust quality control system, and the application of modern theories and technologies in analytical ...
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Strategies for Quality Control of Polysaccharides in Chinese Medicines
Polysaccharides with multiple biological activities are usually considered as one of the major bioactive compounds in Chinese medicines (CMs). At present, the development of drugs and functional foods related ...
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Bio-Specific Extraction/Receptor Fishing for Screening of Active Components in Chinese Medicines
In this chapter, the principles and processes of bio-specific extraction/receptor fishing, such as equilibrium dialysis, centrifugation, and material-based ligand screening assay, are briefly introduced, respe...
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Application of Supercritical Fluid Extraction in Quality Control of Chinese Medicines
Traditional Chinese medicine (TCMs), as an important branch of medicine, has been used in the treatment of various diseases in East Asia for thousands of years. However, due to the complexity of TCMs, the deve...
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Correction to: Therapeutics and Diagnostics Discovery
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Chapter
Aquaporins in Edema
One of the most prevalent indications of water–electrolyte imbalance is edema. Aquaporins (AQPs) are a protein family that can function as water channels. Osmoregulation and body water homeostasis are dependen...
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Non-Transport Functions of Aquaporins
Although it has been more than 20 years since the first aquaporin was discovered, the specific functions of many aquaporins are still under investigation, because various mice lacking aquaporins have no signif...