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    Chapter

    Physical Stabilization of Proteins in Aqueous Solution

    The formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native s...

    Brent S. Kendrick, Tiansheng Li in Rational Design of Stable Protein Formulat… (2002)

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    Chapter

    Recombinant Production of Native Proteins from Escherichia coli

    The production of large quantities of proteins became possible with the advent of recombinant DNA technology, and the subsequent expression of recombinant proteins in Escherichia coli (E. coli) (Itakura, 1977). R...

    Tsutomu Arakawa, Tiansheng Li in Rational Design of Stable Protein Formulat… (2002)

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    Chapter

    Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors

    Brain tumors present a great therapeutic challenge due to their very poor prognosis (Mahaley et al, 1989). On the other hand, brain tumors have some features that make them particularly attractive for in vivo ...

    Jianhong Zhu, Li Zhang, Regina Reszka in Targeting of Drugs 5 (1996)

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    Chapter

    Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission

    Some noradrenergic noncholinergic (NANC) autonomic and enteric nerves utilize NO or an NO-like factor as a transmitter and have been termed nitrergic. They contain a characteristic neuronal isozyme of NO synth...

    Professor Michael J. Rand, Chun Guang Li in Pharmacological Sciences: Perspectives for… (1995)

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    Chapter

    Neuroendocrine Hormones and the Immune System

    From ancient times up to the present, there have been anecdotal observations of an association between “personality,” health and disease. Today, we are confronted with the apparent reality of the association a...

    Paul A. Kelly, J. Edwin Blalock in Pharmacological Sciences: Perspectives for… (1995)

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    Chapter and Conference Paper

    Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes

    Within the past decade it has become widely accepted that the entry into the hepatocyte of low molecular weight amphipathic organic compounds which are albumin-bound within the circulation is mediated by membr...

    Paul D. Berk, Barry J. Potter, Dario Sorrentino in Hepatic Transport of Organic Substances (1989)