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Chapter
Physical Stabilization of Proteins in Aqueous Solution
The formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native s...
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Chapter
Recombinant Production of Native Proteins from Escherichia coli
The production of large quantities of proteins became possible with the advent of recombinant DNA technology, and the subsequent expression of recombinant proteins in Escherichia coli (E. coli) (Itakura, 1977). R...
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Chapter
Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors
Brain tumors present a great therapeutic challenge due to their very poor prognosis (Mahaley et al, 1989). On the other hand, brain tumors have some features that make them particularly attractive for in vivo ...
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Chapter
Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission
Some noradrenergic noncholinergic (NANC) autonomic and enteric nerves utilize NO or an NO-like factor as a transmitter and have been termed nitrergic. They contain a characteristic neuronal isozyme of NO synth...
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Chapter
Neuroendocrine Hormones and the Immune System
From ancient times up to the present, there have been anecdotal observations of an association between “personality,” health and disease. Today, we are confronted with the apparent reality of the association a...
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Chapter and Conference Paper
Characteristics of Organic Anion Binding Proteins from Rat Liver Sinusoidal Plasma Membranes
Within the past decade it has become widely accepted that the entry into the hepatocyte of low molecular weight amphipathic organic compounds which are albumin-bound within the circulation is mediated by membr...