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within
Biomedicine
Qi** Li
Chapter
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Chapter
Problems Related to the Protein-Eliciting Experimental Allergic Encephalomyelitis
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease with central nervous system (CNS) involvement. The compound responsible for the condition is a basic protein and derives from the CNS myel...
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Chapter
Biochemical Actions of Fibroblast Kinin-Forming Protease
Both a neutral (1) and acid (2,3) protease capable of forming kinins from a variety of mammalian substrates have been isolated and purified from the transplanted rodent Murphy-Sturm lymphosarcoma (MSLS). The M...
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Chapter
Pharmacokinetics and Metabolism of Anticancer Drugs
The design of cancer chemotherapeutic agents would already have evolved from empiricism to rationalism if a unique structural feature exists that specifically confers anticancer activity on a chemical substanc...
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Chapter
Environmental Toxicology
Synthetic organic pesticides when used properly have been of tremendous benefit to man and his environment, but when misused or used carelessly they have caused considerable harm. Fortunately, the adverse effe...
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Chapter
Brain Glycosidases
In kee** with the complexity of the CNS, the characteristics and biological roles of the brain glycosidases have been more difficult to define than in visceral organs. The nature of subcellular fractions iso...
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β-Endorphin: initial clinical studies
β-endorphin is an endogenous opiate-like peptide isolated from human pituitary glands in 1976 by Li and associates (Li et al. 1976). Subsequently, human) β-endorphin has been synthesized (Li et al. 1977), and its...
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ß-endorphin: stimulation of DNA-dependent RNA formation
Many hormones have been shown to alter gene expression with resultant stimulation of protein and/or RNA synthesis in target cells and, in some instances, inhibition of protein synthesis (Hamilton, 1968; Tata,...
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Demonstration of the analgesic activity of human β-endorphin in six patients
It has been demonstrated that the untriakontapeptide β-endorphin produces more potent analgesia in animals than morphine, on a molar basis (Loh et al. 1976; Tseng etal. 1976a; Meglio et al. 1977; Feldberg and Smy...
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Structure—activity relationships of ß-endorphin by synthesis —1977
During isolation of melanotropins from camel pituitary glands (Li et al., 1975), we were unable to find β-LPH, but obtained an untriakontapeptide (Li and Chung, 1976a) with an amino acid sequence identical to the...
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Enzymic Degradation of Gangliosides
As in the case for the enzymic degradation of sugar chains in other glycoconjugates, the following considerations should be made in investigating the enzymic degradation of saccharide chains in gangliosides. O...
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Half-Sib Analysis of Quantitative Data
The nonexperimental study of population biology usually depends on the availability of data from the population under study. Thus, in a society where adoption of children is practiced, we may study foster pare...
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Transforming Activity of Viruses after Dye—Light Inactivation
The phenomenon of photodynamie inactivation was first reported by Raab (1) at the beginning of this century (he observed that paramecia lived while suspended in acridine orange solution and kept in the dark, b...
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Changes in Phosphoglycerides and Their Acyl Group Profiles of Glioma Cells Due to Butyrate Treatment
Butyrate treatment of F98 clonal glioma cell line is known to induce cell differentiation and result in expression of new phenotypes (Ko & Koestner, J. Natl. Cancer Inst. 65(5): 1017–1027, 1980). In this exper...
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ButyRate-Induced Expression of Selected Glial Markers by Clonal Glioma (F98) Cells in Vitro
The phenotypic expression of two glia-specific markers, S-100 protein and glial fibrillary acidic protein (GFAP), during exposure to sodium butyrate (SB) at 2.5 mM by clonal glioma cells was studied.
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Chapter
Biochemical Studies of Tay-Sachs Disease
Tay-Sachs disease (GM2-gangliosidosis) is one of the most common ganglioside storage diseases characterized by the accumulation of a large amount of GM2 ganglioside (Tay-Sachs ganglioside) in the neural tissue...
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Benzodiazepine-Binding Site and Gaba-Binding Site
There is a body of experimental evidence to suggest that the benzodiazepine-binding site, the GABA-binding site and the chloride ionophore are functionally correlated. To elucidate this issue, the interactions...
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Chapter and Conference Paper
Indications of Optical Coherence in Biological Systems and Its Possible Significance
The widespread, if not general phenomenon of “ultraweak” photon emission from living cells and organisms, which is different from bioluminescence1), has been extensively 2–4) reviewed The measurements are carried...
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Butyrate-Induced Reverse Transformation of Clonal Glioma Cells in Vitro
Clonal glioma (F98) cells were derived from an undifferentiated neurogenic tumor transplacentally induced by N-ethyl-N-nitrosourea in the CD Fischer rat. In vitro, these cells retain the characteristic autonomous...
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Chapter
Choline Acetyltransferase: Purification, Characterization, Localization, and Induction of a Fatal Autoimmune Disease
Choline acetyltransferase (ChAc; acetyl-CoA: Choline-O-acetyltransferase, EC 2.3.1.6) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) and is the specific enzymatic maker for cholinergic neu...
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Activator Proteins for the Catabolism of Glycosphingolipids
After Büchner’s discovery in 18971 that the alcoholic fermentation of glucose could be carried out by yeast-juice (cell free extract of yeast), Harden and Young2 reported in 1904 that the fermentation of glucose ...
