219 Result(s)
within
Chapter
Qi** Li
Biomedicine
Immunology
-
Chapter
Etiology of HFMD
Hand, foot, and mouth disease (HFMD) is caused by multiple viruses in the genus Enterovirus, which include the well-known polioviruses (PVs), coxsackieviruses A and B (CV-A and CV-B), and enteric cytopathic hu...
-
Chapter
The Expression of Non B Cell-Derived Immunoglobulins
Although V(D)J recombination and immunoglobulin (Ig) production are traditionally recognised to occur only in B lymphocytes and plasma cells, the expression of Igs in non-lymphoid cells, which we call non B ce...
-
Chapter
Exotoxins of Staphylococcus aureus
Staphylococcus aureus produces a variety of exotoxins, which are important virulence factors for S. aureus-related diseases. Representatively, staphylococcal enterotoxins induce staphylococcal food-born poisoning...
-
Chapter
Pathogen–Host Interaction and Its Associated Molecular Mechanism in HFMD Pathology and Immunology
Hand, foot, and mouth disease (HFMD) is caused by the enterovirus family, which includes EV-A71 and more than 10 other members. The disease involves a complex pathological mechanism that includes intricate and...
-
Chapter
The Structure Characteristics and Function of Non B Cell-Derived Immunoglobulin
According to classical immunology theory, immunoglobulin (Ig) is exclusively produced by differentiated B lymphocytes, which exhibit a typical tetrapeptide chain structure and are predominantly present on the ...
-
Chapter
Liver Cancer: Interdisciplinary Approach
Liver cancer is currently the fifth most common malignant tumor and the second leading cause of tumor deaths. Its pathogenesis is extremely complex, involving multiple signaling pathways such as VEGFR, EGFR, R...
-
Chapter
Animal Models of Tuberculosis
Tuberculosis (TB) is an important zoonotic disease caused by infection with Mycobacterium tuberculosis (Mtb) complex and has a significant impact on public health. Animal models are suitable tools to mimic the cl...
-
Chapter and Conference Paper
Critical Role of VEGF as a Direct Regulator of Photoreceptor Function
Vascular endothelial growth factor (VEGF or VEGF-A), a major pathogenic factor for diabetic and hypoxic blood–retina barrier (BRB) diseases, has been shown to act as a direct functional regulator for neurons i...
-
Chapter and Conference Paper
Generation of CRB1 RP Patient-Derived iPSCs and a CRISPR/Cas9-Mediated Homology-Directed Repair Strategy for the CRB1 c.2480G>T Mutation
Mutations in the Crumbs-homologue-1 (CRB1) gene lead to a spectrum of severe inherited retinal diseases, including retinitis pigmentosa (RP). The establishment of a genotype–phenotype correlation in CRB1 patients...
-
Chapter
Pseudotyped Viruses for Mammarenavirus
Mammarenaviruses are classified into New World arenaviruses (NW) and Old World arenaviruses (OW). The OW arenaviruses include the first discovered mammarenavirus-lymphocytic choriomeningitis virus (LCMV) and t...
-
Chapter
Pseudotyped Viruses for Marburgvirus and Ebolavirus
Marburg virus (MARV) and Ebola virus (EBOV) of the Filoviridae family are the most lethal viruses in terms of mortality rate. However, the development of antiviral treatment is hampered by the requirement for bio...
-
Chapter
Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration
Articular cartilage is a hydrated macromolecular composite mainly composed of type II collagen fibrils and the large proteoglycan, aggrecan. Aggrecan is a key determinant of the bearing and energy dissipatio...
-
Chapter
Nitric Oxide and Cardiovascular Health
Nitric oxide (NO) is a diffusible free radical and universal messenger that is produced from L-arginine by three different isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endoth...
-
Chapter
Drug Resistance in Hepatocellular Carcinoma
At present, the burden of cancer morbidity and mortality is increasing all over the world. Among all kinds of cancer, primary liver cancer is discovered to be the seventh most common cancer and has an extremel...
-
Chapter
Pseudotyped Viruses
Pseudotyped viruses have been constructed for many viruses. They can mimic the authentic virus and have many advantages compared to authentic viruses. Thus, they have been widely used as a surrogate of authent...
-
Chapter
Pseudotyped Viruses for Orthohantavirus
Orthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense, single-stranded, tripartite RNA viruses. They are emerging zoonotic pathoge...
-
Chapter
Pseudotyped Virus for Henipavirus
The genus Henipavirus (HNV) includes two virulent infectious viruses, Nipah virus (NiV) and Hendra virus (HeV), which are the focus of considerable public health research efforts and have been classified as prior...
-
Chapter
Hypoxia in Drug Resistance and Radioresistance
Tumors mostly experience hypoxia or hypoxic stress as they progress, especially for tumor cells that are located far from the functional blood vessels. Pathologically, tumor hypoxia is known to play an importa...
-
Chapter
Brain and Spinal Tumors Originating from the Germ Line Cells
(CNS GCTs) are part of the GCTs in children and adults. This tumor entity presents with geographic variation, age, and sex predilection. There are two age peaks distribution at the first few months of lif...
-
Chapter
Advances in Development of mRNA-Based Therapeutics
Recently, mRNA-based therapeutics have been greatly boosted since the development of novel technologies of both mRNA synthesis and delivery system. Promising results were showed in both preclinical and clinica...
