6 Result(s)
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Chapter
Strategies to Optimize Peptide Stability and Prolong Half-Life
Peptide drugs represent 5% of the global pharmaceutical market, but growing twice as fast as the rest of the drug market. The development of peptide therapeutics is challenging due to their low stability, shor...
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Chapter
Overview of the Impact of Protein Interfacial Instability on the Development of Biologic Products
Interfacial phenomena can significantly affect the development, manufacturing, stability, and use of therapeutic proteins. Proteins are exposed to air-liquid, solid-liquid, and liquid-liquid interfaces through...
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Chapter
Future Perspectives
In this chapter, we describe future perspectives of product development of biologics with an emphasis on the effect of interfacial stress on product performance and development, including analytical detection,...
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Chapter
Physical Stabilization of Proteins in Aqueous Solution
The formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native s...
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Chapter
Recombinant Production of Native Proteins from Escherichia coli
The production of large quantities of proteins became possible with the advent of recombinant DNA technology, and the subsequent expression of recombinant proteins in Escherichia coli (E. coli) (Itakura, 1977). R...
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Chapter
Liposome-Mediated Delivery of Genes and Oligonucleotides for the Treatment of Brain Tumors
Brain tumors present a great therapeutic challenge due to their very poor prognosis (Mahaley et al, 1989). On the other hand, brain tumors have some features that make them particularly attractive for in vivo ...
