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Chapter
Role of CD4 in the Penetration of Cells by HIV
Enveloped viruses penetrate host cells by two distinct. mechanisms: by direct fusion between viral and cell membrane or by receptor-mediated endocytosis. Though not mutually exclusive, it is likely that viruse...
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Chapter and Conference Paper
The Role of CD4 Antigen in HIV Infection
Ever since the initial description of acquired immune deficiency syndrome (AIDS), it has been known that a specific depletion of CD4+ T-lymphocytes in the peripheral blood accompanies the onset of immunodeficienc...
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Chapter and Conference Paper
Neutralization and Receptor Recognition of Human T-Lymphotropic Retroviruses
Like other enveloped viruses, the outer membrane antigens of retroviruses present target antigens for neutralizing antibodies, and also play a key role in interacting with cell-surface receptors for initial st...