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Chapter and Conference Paper
Lipid Gene Trasfer, a Story of Simplicity and Complexity
It is 10 years since the first description of the use of a positively charged lipid to deliver nucleic acids to mammalian cells (Feigner et al., 1987). In essence the methodology of liposome-mediated transfer of ...
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Chapter and Conference Paper
Gene Therapy for Cancer
Cancer is a complex acquired disease that affects millions of individuals each year. Underlying the pathogenesis of cancer are a variety of molecular genetic abnormalities which can be inherited or environment...
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Chapter and Conference Paper
Lipid Gene Transfer and Clinical Gene Therapy
There are several features of liposome-mediated DNA transfer that make it a viable delivery system for clinical gene therapy. 1) In contrast to viral delivery systems, contamination with exogenous protein or o...